Title:
PREPARATION METHOD FOR HEXAHYDROFURO-FURAN-OL DERIVATIVE AND INTERMEDIATE OF DERIVATIVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/174176
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical synthesis, and in particularly relates to a preparation method for a hexahydrofuro-furan-ol derivative, and an intermediate of the derivative and a preparation method therefor. According to the preparation method, a compound represented by formula A1 is used as a starting material; in a preparation process of the hexahydrofuro-furan-ol derivative, an enzymic method is used to construct chirality; and such a technical means can prepare products with very high optical purity. The preparation method can commercialize and prepare a key intermediate (3R, 3aS, 6aR)-hexahydrofuro[2, 3-b]-3-ol of darunavir, which is a very economic way suitable for industrial production.
Inventors:
GAO ZHAOBO (CN)
CHEN JIANHUA (CN)
WAN ZHIDONG (CN)
HE DAWEI (CN)
ZHOU ZENGLE (CN)
MA XIAODONG (CN)
XIANG WEI (CN)
LIN JINGXIN (CN)
MEI YIJIANG (CN)
CHEN JIANHUA (CN)
WAN ZHIDONG (CN)
HE DAWEI (CN)
ZHOU ZENGLE (CN)
MA XIAODONG (CN)
XIANG WEI (CN)
LIN JINGXIN (CN)
MEI YIJIANG (CN)
Application Number:
PCT/CN2018/097733
Publication Date:
September 19, 2019
Filing Date:
July 30, 2018
Export Citation:
Assignee:
JIANGSU RUIKE MEDICAL SCIENCE AND TECH CO LTD (CN)
International Classes:
C07D307/33; C07D493/04; C12P17/04
Foreign References:
| EP2634180A1 | 2013-09-04 | |||
| EP2634180A1 | 2013-09-04 | |||
| CN103896886A | 2014-07-02 | |||
| CN103896886A | 2014-07-02 | |||
| CN103864813A | 2014-06-18 | |||
| CN201810220506A | 2018-03-16 | |||
| CN02817639A | 2002-09-06 | |||
| CN200580010400A | 2005-03-31 | |||
| CN200380109926A | 2003-10-27 | |||
| EP2634180A1 | 2013-09-04 | |||
| EP2634180A1 | 2013-09-04 |
Other References:
See also references of EP 3766874A4
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