Title:
PREPARATION METHOD FOR ISOTHIAZOLO[5,4-D]PYRIMIDINE IRAK4 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/104195
Kind Code:
A1
Abstract:
Provided is a preparation method for an isothiazolo[5,4-d]pyrimidine IRAK4 inhibitor, particularly relating to a preparation method for the compound of formula (I) and an intermediate compound 6 thereof. The method for obtaining the trans isomer has the advantages of mild reaction conditions, short reaction steps, short reaction time, simple post-processing operations, and high isomer purity, and is very well suited to industrial production.
Inventors:
WANG DUZHENG (CN)
GUO MENG (CN)
HOU YONGSHENG (CN)
SONG YONGHUI (CN)
CHENG YING (CN)
SUN LIMING (CN)
JIANG ZHULIAN (CN)
JIN MEIHONG (CN)
GUO MENG (CN)
HOU YONGSHENG (CN)
SONG YONGHUI (CN)
CHENG YING (CN)
SUN LIMING (CN)
JIANG ZHULIAN (CN)
JIN MEIHONG (CN)
Application Number:
PCT/CN2022/138020
Publication Date:
June 15, 2023
Filing Date:
December 09, 2022
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D417/14; C07D513/04
Domestic Patent References:
| WO2021147968A1 | 2021-07-29 | |||
| WO2021194318A1 | 2021-09-30 |
Foreign References:
| CN102627653A | 2012-08-08 |
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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