Title:
PREPARATION METHOD OF NEW COMPOUND OF 4'-THIONUCLEOSIDE AND INTERMEDIATE IN THE PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2019/001292
Kind Code:
A1
Abstract:
A method for preparing a compound of formula T-3 according to route I is disclosed. The method comprises the following steps: a first step of reacting a compound of formula T-1 with a reagent comprising a PG group in the presence of an organic base or an inorganic base, optionally under the catalysis of a catalyst, to form a compound of formula T-2; and a second step of reacting the compound of formula T-2 under the catalysis of an organic base or an inorganic base to form the compound of formula T-3. A method for preparing a compound of formula (I)-1 according to route II is further disclosed. The method comprises the following steps: step A, reacting T-3 with R-1 in the presence of a hydroxyl hydrogen removal reagent to obtain a compound of formula T-4; and step B, reacting the compound of formula T-4 under the catalysis of an organic base or an inorganic base, or in the presence of a fluorine-containing reagent, to obtain the compound of formula (I)-1. In addition, an intermediate in the above preparation methods is further disclosed.
Inventors:
ZHOU JIANGFENG (CN)
LIANG YUFENG (CN)
WANG QIANG (CN)
WANG TAO (CN)
HAN WEIBIAO (CN)
LI YOUQIANG (CN)
WEI HAIDONG (CN)
GE JIANHUA (CN)
ZHAO ZHONGQIONG (CN)
WEN QIANYING (CN)
WU LINGJING (CN)
TIAN QIANG (CN)
ZHAO MINGLIANG (CN)
ZENG HONG (CN)
CAI JIAQIANG (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
LIANG YUFENG (CN)
WANG QIANG (CN)
WANG TAO (CN)
HAN WEIBIAO (CN)
LI YOUQIANG (CN)
WEI HAIDONG (CN)
GE JIANHUA (CN)
ZHAO ZHONGQIONG (CN)
WEN QIANYING (CN)
WU LINGJING (CN)
TIAN QIANG (CN)
ZHAO MINGLIANG (CN)
ZENG HONG (CN)
CAI JIAQIANG (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2018/091514
Publication Date:
January 03, 2019
Filing Date:
June 15, 2018
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07H19/06; C07F7/18; C07H1/00; C07H19/10; C07H19/16; C07H19/20
Domestic Patent References:
| WO2016155593A1 | 2016-10-06 | |||
| WO2014197578A1 | 2014-12-11 |
Foreign References:
| JP2014189499A | 2014-10-06 | |||
| CN104540803A | 2015-04-22 |
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD (CN)
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