Title:
PREPARATION METHOD FOR POLYMORPHIC 6-(4-CHLOROPHENOXY)-TETRAZOLO[5,1-A]PHTHALAZINE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/123801
Kind Code:
A1
Abstract:
Disclosed in the present invention is a preparation method for polymorphic 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine and use thereof. New crystal forms are comprehensively characterized by X-ray powder diffraction, thermogravimetic analysis, differential scanning calorimetry, infrared, Raman, hygroscopic analysis and the like. The stability, hygroscopic property and the solubility of the four new crystal forms are compared, which provides references for selecting a best solid form of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine used in medicine development. The preparation method for the new crystal form of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine of the present invention is simple, easy to control, has good reproducibility, and can obtain target crystal forms stably.
Inventors:
QUAN ZHESHAN (CN)
LI WEI (CN)
DONG FANGYAN (CN)
YU YINGZHOU (CN)
LI WEI (CN)
DONG FANGYAN (CN)
YU YINGZHOU (CN)
Application Number:
PCT/CN2014/000946
Publication Date:
August 27, 2015
Filing Date:
October 27, 2014
Export Citation:
Assignee:
JILIN YINGLIAN SHANGDE SCIENCE AND TECHNOLOGY DEV CO LTD (CN)
International Classes:
C07D487/04; A61K31/5025; A61P25/08
Foreign References:
| CN101676287A | 2010-03-24 | |||
| CN103819477A | 2014-05-28 |
Other References:
See also references of EP 3002286A4
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