Title:
PREPARATION METHOD OF POLYVINYL ALCOHOL-ACRYLAMIDE -AGAROSE HYDROGELWITH HIGH MECHANICAL STRENGTH
Document Type and Number:
WIPO Patent Application WO/2023/024055
Kind Code:
A1
Abstract:
Provided is a method for preparing polyvinyl alcohol-acrylamide-agarose hydrogel with high mechanical strength. Polyvinyl alcohol and acrylamide are used as matrix materials, and a small amount of agarose is added. The acrylamide molecules form the first network on the application of a chemical cross linking agent. The polyvinyl alcohol molecules physically crosslink with each other in freeze-thawing cycle and form the second network. Agarose can form hydrogen bonds with the molecular chains of polyvinyl alcohol and acrylamide, which further improves the mechanical strength of the hydrogel. Additionally, the introduction of agarose enables the hydrogel to adhere chondrocyte and promote chondrocyte proliferation. The hydrogel prepared by this method has the potential to be applied in articular cartilage replacement.
Inventors:
ZHANG WEI (CN)
LI JINMING (CN)
LI HENG (CN)
WU CHENGWEI (CN)
LI JINMING (CN)
LI HENG (CN)
WU CHENGWEI (CN)
Application Number:
PCT/CN2021/114907
Publication Date:
March 02, 2023
Filing Date:
August 27, 2021
Export Citation:
Assignee:
UNIV DALIAN TECH (CN)
International Classes:
C08F251/00; C08J3/075; C08F261/04; C08L5/12; C08L29/04
Foreign References:
| CN112920429A | 2021-06-08 |
Other References:
AZAR， M. G. ET AL.: "Tough and Flexible Conductive Triple Network Hydrogels Based on Agarose/polyacrylamide/polyvinyl alcolhol and Poly(3，4-ethylenedioxythiophene): Polystyrene Sulfonate", POLYMER INTERNATIONAL, vol. 70, no. 10, 21 April 2021 (2021-04-21), pages 1523 - 1533, ISSN: 0959-8103
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