Title:
PREPARATION METHOD FOR (R)-O-CHLOROMANDELIC ACID AND CYCLIC BIOENZYME CATALYTIC REACTION SYSTEM FOR THE PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2020/088510
Kind Code:
A1
Abstract:
The present invention relates to a preparation method for (R)-o-chloromandelic acid. By means of the preparation method, the present invention improves the utilization rate of a reaction buffer, thereby reducing the production cost of (R)-o-chloromandelic acid, significantly reducing the discharge of the waste liquid, and achieving the environmentally friendly production of (R)-o-chloromandelic acid. Meanwhile, the preparation method of the present invention has good separation effect, high yield, the strong basic anionic resin used has a long service life, and the separated aqueous phase system can continue to provide a reaction system for the next biological catalysis, thereby reducing production cost and reducing the discharge of waste water. The present invention also relates to a cyclic bioenzyme catalytic reaction system for the preparation method for (R)-o-chloromandelic acid. Said catalytic reaction system simplifies the production operation and improves the working efficiency. The present invention also relates to a process for preparing (R)-o-clomandelic acid using the cyclic bioenzyme catalytic reaction system.
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Inventors:
ZHAO TAOTAO (CN)
HAN RUI (CN)
WANG ZHAOPU (CN)
ZHANG WEI (CN)
WANG CHENG (CN)
ZHANG QI (CN)
HAN RUI (CN)
WANG ZHAOPU (CN)
ZHANG WEI (CN)
WANG CHENG (CN)
ZHANG QI (CN)
Application Number:
PCT/CN2019/114309
Publication Date:
May 07, 2020
Filing Date:
October 30, 2019
Export Citation:
Assignee:
WUHAN WUYAO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C51/42; C12P7/42; C07C51/47; C07C59/56; C12M1/00; C12M1/02; C12M1/34; C12M1/40
Foreign References:
| CN110172401A | 2019-08-27 | |||
| CN110184308A | 2019-08-30 | |||
| CN110172021A | 2019-08-27 | |||
| CN201510978973A | 2015-12-23 |
Other References:
WANG, HUALEI: "Efficient Discovery of Novel Nitrilase and Its Applications Research on Production of Optically Pure α-hydroxylcarboxylic Acid", DOCTORAL DISSERTATION, 31 December 2014 (2014-12-31), pages 1 - 122, XP009520596
XUE, YAPING, ET AL.: "A Novel Integrated Bioprocess for Efficient Production of (R)-(-)-Mandelic Acid with Immobilized Alcaligenes Faecalis ZJUTB10", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 17, no. 2, 15 January 2013 (2013-01-15), pages 213 - 220, XP055698244, ISSN: 1083-6160, DOI: 10.1021/op3001993
See also references of EP 3875594A4
XUE, YAPING, ET AL.: "A Novel Integrated Bioprocess for Efficient Production of (R)-(-)-Mandelic Acid with Immobilized Alcaligenes Faecalis ZJUTB10", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 17, no. 2, 15 January 2013 (2013-01-15), pages 213 - 220, XP055698244, ISSN: 1083-6160, DOI: 10.1021/op3001993
See also references of EP 3875594A4
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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