Title:
PREPARATION METHOD FOR SEMAGLUTIDE, AND INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2024/032081
Kind Code:
A1
Abstract:
The present invention provides a preparation method for semaglutide, and an intermediate. The preparation method comprises the steps of: (1) reacting compound SEM110 and compound SEM120 in a solvent under an alkaline condition to obtain compound SEM130; and (2) deprotecting the compound SEM130 to form semaglutide, the reaction formula being as follows. The preparation method of the present invention is simple to operate, has mild reaction conditions, is easy to purify, has high product purity and low cost, and is suitable for industrial production.
Inventors:
GUO WANCHENG (CN)
FANG JIE (CN)
DUAN YONGLI (CN)
ZHANG FUCHANG (CN)
WANG GUOPING (CN)
YU ZHENPENG (CN)
YANG YINGRUI (CN)
FANG JIE (CN)
DUAN YONGLI (CN)
ZHANG FUCHANG (CN)
WANG GUOPING (CN)
YU ZHENPENG (CN)
YANG YINGRUI (CN)
Application Number:
PCT/CN2023/095654
Publication Date:
February 15, 2024
Filing Date:
May 23, 2023
Export Citation:
Assignee:
YANGZHOU AURISCO PHARMACEUTICAL CO LTD (CN)
AURISCO PHARMACEUTICAL TIANJIN INC (CN)
AURISCO PHARMACEUTICAL TIANJIN INC (CN)
International Classes:
C07K14/605; C07C231/12; C07C237/22; C07C303/30; C07C309/66; C07D209/56; C07K1/02; C07K1/06
Foreign References:
| CN115197312A | 2022-10-18 | |||
| CN111378028A | 2020-07-07 | |||
| CN111253287A | 2020-06-09 | |||
| CN113667006A | 2021-11-19 | |||
| CN110423251A | 2019-11-08 | |||
| CN113461801A | 2021-10-01 |
Attorney, Agent or Firm:
YANGZHOU AURISCO PHARMACEUTICAL CO., LTD (CN)
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