Title:
PREPARATION METHOD FOR SERTACONAZOLE NITRATE CRYSTAL FORM
Document Type and Number:
WIPO Patent Application WO/2023/004915
Kind Code:
A1
Abstract:
A preparation method for a sertaconazole nitrate crystal form, which is used for preparing a sertaconazole nitrate crystal form having a melting point of 156-161°C and which comprises the following steps: A. mixing a crude product of sertaconazole nitrate with an ethanol aqueous solution having a concentration of 45-55 mass%, then raising the temperature to reflux; B. adding activated carbon and continuing to reflux; C. after the activated carbon is removed by filtering, cooling down and letting stand for crystallization; and D. filtering to obtain a crystal, and then drying. A sertaconazole nitrate crystal form having a melting point of 156-161°C can be obtained by using the preparation method provided in the present application, which meets requirements for exporting to countries and regions such as the United Kingdom and the European Union.
Inventors:
LIU YU (CN)
WEI JIAHUA (CN)
LI BOFU (CN)
WEI JIAHUA (CN)
LI BOFU (CN)
Application Number:
PCT/CN2021/114844
Publication Date:
February 02, 2023
Filing Date:
August 26, 2021
Export Citation:
Assignee:
HAINAN HAISHEN TONGZHOU PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D409/12; A61K31/4178; A61P31/10
Foreign References:
| CN112694470A | 2021-04-23 | |||
| CN1358719A | 2002-07-17 | |||
| CN101023077A | 2007-08-22 | |||
| CN101022727A | 2007-08-22 | |||
| EP0151477A2 | 1985-08-14 |
Attorney, Agent or Firm:
INTELIGHT IP LAW FIRM (CN)
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