Title:
PREPARATION METHOD FOR SOLUTION CONTAINING FRUCTOSE SODIUM DIPHOSPHATE, USE THEREOF, AND PREPARATION METHOD FOR SODIUM FRUCTOSE DIPHOSPHATE INJECTION
Document Type and Number:
WIPO Patent Application WO/2020/083341
Kind Code:
A1
Abstract:
Provided are a preparation method for a solution containing fructose sodium diphosphate, use thereof, and a preparation method for a fructose sodium diphosphate injection. The preparation method for the solution containing fructose sodium diphosphate comprises performing solid-liquid separation on a yeast reaction solution containing fructose sodium diphosphate, anion exchange resin extraction, decolorization, reverse osmosis treatment and sterilization treatment. The yeast reaction solution is obtained by contacting a sugar-containing material containing glucose and phosphoric acid with yeast. Other dosage forms such as fructose sodium diphosphate injections or fructose sodium diphosphate oral solutions can be further prepared using said method. The preparation method has advantages of greatly reducing the dosage of an organic solvent and reducing the production cost.
Inventors:
WANG SHUO (CN)
WANG HONGPING (CN)
WANG HONGPING (CN)
Application Number:
PCT/CN2019/113049
Publication Date:
April 30, 2020
Filing Date:
October 24, 2019
Export Citation:
Assignee:
BEIJING HUAJIN PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K9/08; A61K31/7024; A61P3/12; A61P9/10; C12P19/12; C12R1/865
Foreign References:
| CN109223709A | 2019-01-18 | |||
| CN1089655A | 1994-07-20 | |||
| CN1089654A | 1994-07-20 | |||
| CN107595770A | 2018-01-19 | |||
| CN101244071A | 2008-08-20 | |||
| US4920049A | 1990-04-24 | |||
| US5501965A | 1996-03-26 |
Other References:
于明安等 (YU, MING'AN ET AL.),: "CTAB透性啤酒酵母生物合成高浓度二磷酸果糖 (Biosynthesis of High Concentration Fructose Diphosphate Using CTAB Permeabilized Brewer's Yeast),", 生物医学工程学杂志 (JOURNAL OF BIOMEDICAL ENGINEERING), vol. 12, no. 2, 31 December 1995 (1995-12-31)
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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