Title:
PREPARATION METHOD FOR TGF-β-INHIBITING ANTI-TUMOR DRUG
Document Type and Number:
WIPO Patent Application WO/2023/142985
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of drug synthesis. Disclosed is a preparation method for a TGF-β-inhibiting anti-tumor drug. Compared with preparation methods in the existing technology, the number of reaction steps are reduced in the method of the present invention, thus reducing costs; the use of high-temperature reactions is reduced, avoiding the use of highly toxic and flammable reagents; and the total yield is increased from 13% in methods in the existing technology to 32%.
Inventors:
XIA DONGLIANG (CN)
TAN SHIJIE (CN)
WANG TAO (CN)
LIU ZHIHUAN (CN)
YAN JUAN (CN)
WAN HUI (CN)
QI HONGXIA (CN)
LIANG YUFENG (CN)
SONG HONGMEI (CN)
GE JUNYOU (CN)
TAN SHIJIE (CN)
WANG TAO (CN)
LIU ZHIHUAN (CN)
YAN JUAN (CN)
WAN HUI (CN)
QI HONGXIA (CN)
LIANG YUFENG (CN)
SONG HONGMEI (CN)
GE JUNYOU (CN)
Application Number:
PCT/CN2023/071173
Publication Date:
August 03, 2023
Filing Date:
January 09, 2023
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D231/10; C07D471/04; C07D231/54; C07D451/00; C07D487/04
Domestic Patent References:
| WO2018107056A1 | 2018-06-14 |
Foreign References:
| CN112939967A | 2021-06-11 |
Other References:
GENIN, MICHAEL J. ET AL.: "Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious Gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 5, 17 February 2000 (2000-02-17), XP002975106, ISSN: 1520-4804, DOI: 10.1021/jm990373e
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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