Title:
PREPARATION METHOD FOR TUMOR INFILTRATING LYMPHOCYTE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/135525
Kind Code:
A1
Abstract:
Provided are a preparation method for a tumor infiltrating lymphocyte, and a use thereof, particularly relating to a method for culturing a tumor infiltrating lymphocyte, comprising: subjecting a TIL, which is derived from tumor tissues and not amplified in vitro, to in vitro amplification of at least one stage, wherein the TIL is brought into contact with a CD28 agonist in the in vitro amplification of at least one stage. Further provided is a method for preventing and/or treating tumors by means of using the tumor infiltrating lymphocyte.
Inventors:
LIU YARONG (CN)
ZHAO PEIPEI (CN)
ZHAO PEIPEI (CN)
Application Number:
PCT/CN2021/140841
Publication Date:
June 30, 2022
Filing Date:
December 23, 2021
Export Citation:
Assignee:
SUZHOU GRIT BIOTECHNOLOGY CO LTD (CN)
SHANGHAI GRIT BIOTECHNOLOGY CO LTD (CN)
ZHUHAI TUOYU BIOTECHNOLOGY CO LTD (CN)
ZHUHAI GRIT BIOTECHNOLOGY CO LTD (CN)
SHANGHAI GRIT BIOTECHNOLOGY CO LTD (CN)
ZHUHAI TUOYU BIOTECHNOLOGY CO LTD (CN)
ZHUHAI GRIT BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N5/0783; A61K35/17; A61P35/00; C12N5/09
Domestic Patent References:
| WO2020172202A1 | 2020-08-27 | |||
| WO2020232029A1 | 2020-11-19 |
Foreign References:
| CN111801415A | 2020-10-20 | |||
| US20170246277A1 | 2017-08-31 |
Other References:
ZOCCHI, M.R. ; POGGI, A. ; CROSTI, F. ; TONGIANI, S. ; RUGARLI, C.: "Signalling in human tumour infiltrating lymphocytes: The CD28 molecule is functional and is physically associated with the CD45R0 molecule", EUROPEAN JOURNAL OF CANCER, ELSEVIER, AMSTERDAM NL, vol. 28, no. 4-5, 1 April 1992 (1992-04-01), Amsterdam NL , pages 749 - 754, XP026207619, ISSN: 0959-8049, DOI: 10.1016/0959-8049(92)90108-E
V BALDAN, R GRIFFITHS, R E HAWKINS, D E GILHAM: "Efficient and reproducible generation of tumour-infiltrating lymphocytes for renal cell carcinoma", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP UK, LONDON, vol. 112, no. 9, 1 April 2015 (2015-04-01), London, pages 1510 - 1518, XP055447344, ISSN: 0007-0920, DOI: 10.1038/bjc.2015.96
SHANSHAN JIANG, YAN TANG, KE PAN, DESHENG WENG, JINGJING ZHAO, JIA HE, JIANCHUAN XIA: "In Vitro Culturing and Characteristics of Tumor-infi ltrating Lymphocyte of Hepatocellular Carcinoma", CHINESE JOURNAL OF CELL BIOLOGY, ZHONGGUO KEXUEYUAN SHANGHAI SHENGMING KEXUE YANJIUYUAN SHENGWU HUAXUE YU XIBAO SHENGWUXUE YANJIUSUO, CN, vol. 36, no. 7, 1 July 2014 (2014-07-01), CN , pages 970 - 975, XP055874789, ISSN: 1674-7666, DOI: 10.11844/cjcb.2014.07.0367
SANTOIEMMA PHILLIP P, POWELL DANIEL J: "Tumor infiltrating lymphocytes in ovarian cancer", CANCER BIOLOGY & THERAPY, LANDES BIOSCIENCE, US, vol. 16, no. 6, 3 June 2015 (2015-06-03), US , pages 807 - 820, XP055947236, ISSN: 1538-4047, DOI: 10.1080/15384047.2015.1040960
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
KABAT E.A ET AL.: "Sequences of proteins of immunological interest", 1991, NIH PUBLICATION, pages: 91 - 3242
CHOTHIA ET AL.: "Canonical Structures For the Hypervariable Regions of Immunoglobulins", J. MOL. BIOL., vol. 196, 1987, pages 901, XP024010426, DOI: 10.1016/0022-2836(87)90412-8
MACCALLUM ET AL.: "Antibody-Antigen Interactions: Contact Analysis and Binding Site Topography", J. MOL. BIOL., vol. 262, 1996, pages 732, XP002242391, DOI: 10.1006/jmbi.1996.0548
V BALDAN, R GRIFFITHS, R E HAWKINS, D E GILHAM: "Efficient and reproducible generation of tumour-infiltrating lymphocytes for renal cell carcinoma", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP UK, LONDON, vol. 112, no. 9, 1 April 2015 (2015-04-01), London, pages 1510 - 1518, XP055447344, ISSN: 0007-0920, DOI: 10.1038/bjc.2015.96
SHANSHAN JIANG, YAN TANG, KE PAN, DESHENG WENG, JINGJING ZHAO, JIA HE, JIANCHUAN XIA: "In Vitro Culturing and Characteristics of Tumor-infi ltrating Lymphocyte of Hepatocellular Carcinoma", CHINESE JOURNAL OF CELL BIOLOGY, ZHONGGUO KEXUEYUAN SHANGHAI SHENGMING KEXUE YANJIUYUAN SHENGWU HUAXUE YU XIBAO SHENGWUXUE YANJIUSUO, CN, vol. 36, no. 7, 1 July 2014 (2014-07-01), CN , pages 970 - 975, XP055874789, ISSN: 1674-7666, DOI: 10.11844/cjcb.2014.07.0367
SANTOIEMMA PHILLIP P, POWELL DANIEL J: "Tumor infiltrating lymphocytes in ovarian cancer", CANCER BIOLOGY & THERAPY, LANDES BIOSCIENCE, US, vol. 16, no. 6, 3 June 2015 (2015-06-03), US , pages 807 - 820, XP055947236, ISSN: 1538-4047, DOI: 10.1080/15384047.2015.1040960
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
KABAT E.A ET AL.: "Sequences of proteins of immunological interest", 1991, NIH PUBLICATION, pages: 91 - 3242
CHOTHIA ET AL.: "Canonical Structures For the Hypervariable Regions of Immunoglobulins", J. MOL. BIOL., vol. 196, 1987, pages 901, XP024010426, DOI: 10.1016/0022-2836(87)90412-8
MACCALLUM ET AL.: "Antibody-Antigen Interactions: Contact Analysis and Binding Site Topography", J. MOL. BIOL., vol. 262, 1996, pages 732, XP002242391, DOI: 10.1006/jmbi.1996.0548
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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