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Patent Searching and Data


Title:
PREPARATION METHOD FOR TYROSINE KINASE INHIBITOR AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/076316
Kind Code:
A1
Abstract:
Provided is a preparation method for a tyrosine kinase inhibitor and an intermediate thereof. Specifically, a preparation method for a cyanoquinoline compound is provided. The method has a high yield, good product purity, and mild reaction conditions.

Inventors:
FENG, Guobing (No.7 Kunlunshan Road, Economic and Technological Development ZoneLianyungang, Jiangsu 7, 222047, CN)
CAO, Yongxing (No.7 Kunlunshan Road, Economic and Technological Development ZoneLianyungang, Jiangsu 7, 222047, CN)
ZHANG, Peng (No.7 Kunlunshan Road, Economic and Technological Development ZoneLianyungang, Jiangsu 7, 222047, CN)
QIU, Zhenjun (No.7 Kunlunshan Road, Economic and Technological Development ZoneLianyungang, Jiangsu 7, 222047, CN)
ZHANG, Long (No.7 Kunlunshan Road, Economic and Technological Development ZoneLianyungang, Jiangsu 7, 222047, CN)
Application Number:
CN2018/110615
Publication Date:
April 25, 2019
Filing Date:
October 17, 2018
Export Citation:
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Assignee:
JIANGSU HENGRUI MEDICINE CO., LTD. (No.7 Kunlunshan Road, Economic and Technological Development ZoneLianyungang, Jiangsu 7, 222047, CN)
International Classes:
C07D407/14; C07D209/48; C07D213/30; C07D215/54; C07D401/12; C07D495/04
Foreign References:
CN101180269A2008-05-14
CN101478964A2009-07-08
CN105330646A2016-02-17
CN102020639A2011-04-20
Other References:
SCHAFER HARRY: "Zur Synthese von 4-Aminochinolinen durch intramolekularo Friedel-Crafts-Reaktion", MONATSHEFTE FUR CHEMIE, vol. 109, 31 December 1978 (1978-12-31), XP000945286, DOI: doi:10.1007/BF00912769
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (21st Floor SFECO Mansion 681 Xiaomuqiao Road, Shanghai 2, 200032, CN)
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