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Title:
PREPARATION METHOD FOR TYROSINE KINASE INHIBITOR AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/076316
Kind Code:
A1
Abstract:
Provided is a preparation method for a tyrosine kinase inhibitor and an intermediate thereof. Specifically, a preparation method for a cyanoquinoline compound is provided. The method has a high yield, good product purity, and mild reaction conditions.

Inventors:
FENG GUOBING (CN)
CAO YONGXING (CN)
ZHANG PENG (CN)
QIU ZHENJUN (CN)
ZHANG LONG (CN)
Application Number:
CN2018/110615
Publication Date:
April 25, 2019
Filing Date:
October 17, 2018
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Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
C07D407/14; C07D209/48; C07D213/30; C07D215/54; C07D401/12; C07D495/04
Domestic Patent References:
WO2011029265A12011-03-17
Foreign References:
CN101180269A2008-05-14
CN101478964A2009-07-08
CN105330646A2016-02-17
CN102020639A2011-04-20
CN201710978352A2017-10-18
CN102933574A2013-02-13
CN101180269A2008-05-14
CN100537518C2009-09-09
Other References:
SCHAFER HARRY: "Zur Synthese von 4-Aminochinolinen durch intramolekularo Friedel-Crafts-Reaktion", MONATSHEFTE FUR CHEMIE, vol. 109, 31 December 1978 (1978-12-31), XP000945286, DOI: doi:10.1007/BF00912769
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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