Title:
PREPARATION METHODS OF AMINOMETHYL BIPHENYL TETRAZOLE COMPOUNDS AND THEIR SALTS, INTERMEDIATES AND PREPARATION METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/086753
Kind Code:
A1
Abstract:
Preparation methods of aminomethyl biphenyl tetrazole compounds of formula
I or their salts and salts of formula II comprise that intermediates of formula
III are reduced by reducing agents in an inert organic solvent to obtain aminomethyl
biphenyl tetrazole compounds or their salts (formula I), followed by acidification
to obtain their salts (formula II); alternatively, intermediates of formula
III are reduced in acidic condition to obtain their salts directly (formula II),
in which M is hydrogen or alkali metals or C3-C18 tertiary
amine salts, X is Cl,Br,HSO4 or CH3COO. Intermediates of
formula III and their preparation methods. The present methods have advantages
of abundance source for the raw materials, low cost, simple operation for synthesizing
steps, mild reaction conditions, easy purification of products, high purity
of products such as 99.5% and high yield. So the present methods are suitable for
both small scale in the laboratory and industrial process.
Inventors:
WANG PING (CN)
PAN QIANGBIAO (CN)
ZOU BENLI (CN)
PENG YECHENG (CN)
BAO MEIJUN (CN)
PAN QIANGBIAO (CN)
ZOU BENLI (CN)
PENG YECHENG (CN)
BAO MEIJUN (CN)
Application Number:
PCT/CN2008/073070
Publication Date:
July 16, 2009
Filing Date:
November 14, 2008
Export Citation:
Assignee:
LIANHE CHEMICAL TECHNOLOGY CO (CN)
WANG PING (CN)
PAN QIANGBIAO (CN)
ZOU BENLI (CN)
PENG YECHENG (CN)
BAO MEIJUN (CN)
WANG PING (CN)
PAN QIANGBIAO (CN)
ZOU BENLI (CN)
PENG YECHENG (CN)
BAO MEIJUN (CN)
International Classes:
C07D257/04
Domestic Patent References:
| WO2007017469A2 | 2007-02-15 |
Foreign References:
| US5234936A | 1993-08-10 | |||
| US5336677A | 1994-08-09 |
Attorney, Agent or Firm:
SHANGHAI ZHI XIN PATENT AGENT LTD. (Zhijun Building No.1223 Xietu Road, Shanghai 2, CN)
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