PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE

WIPO Patent Application WO1994026723

A3

Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protein transferase is indicated.

MARSTERS JAMES C JR (US)
BROWN MICHAEL S (US)
CROWLEY CRAIG W (US)
GOLDSTEIN JOSEPH L (US)
JAMES GUY L (US)
MCDOWELL ROBERT S (US)
OARE DAVID (US)
RAWSON THOMAS E (US)
REYNOLDS MARK (US)
SOMERS TODD G (US)

PCT/US1994/005157

February 02, 1995

May 10, 1994

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GENENTECH INC (US)
UNIV TEXAS (US)
MARSTERS JAMES C JR (US)
BROWN MICHAEL S (US)
CROWLEY CRAIG W (US)
GOLDSTEIN JOSEPH L (US)
JAMES GUY L (US)
MCDOWELL ROBERT S (US)
OARE DAVID (US)
RAWSON THOMAS E (US)
REYNOLDS MARK (US)
SOMERS TODD G (US)

A61K31/55; A61K31/551; A61P31/04; A61P35/00; C07D223/16; C07D243/10; C07D243/14; C07D243/24; C07D401/06; C07D401/14; C07D403/04; C07D403/06; C07D403/10; C07D403/12; C07D403/14; C07D405/06; C07D409/06; C07D409/14; C07D417/12; C07D417/14; C07D487/04; C07D498/04; C07D513/04; C07K5/02; C07K5/06; C07K5/078; C07K5/08; C07K5/083; C07K5/097; C07K5/10; C07K5/103; C07K5/117; A61K38/00; (IPC1-7): C07D243/14; C07D223/16; C07D243/24

WO1992001683A1	1992-02-06
WO1994004561A1	1994-03-03

EP0322779A2	1989-07-05
EP0166357A2	1986-01-02
EP0167919A2	1986-01-15
EP0284256A1	1988-09-28
EP0461869A2	1991-12-18
EP0520823A2	1992-12-30

GUY L. JAMES ET AL: "Benzodiazepine peptidomimetics: Potent Inhibitors of RAS Farnesylation in animal cells", SCIENCE, vol. 260, 25 June 1993 (1993-06-25), pages 1937 - 1942

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