Title:
PREPARATION OF NANO-ENHANCED CHIP AND USE THEREOF IN LASER DISSOCIATION MASS SPECTROMETRY DETECTION OF SMALL MOLECULE METABOLITE
Document Type and Number:
WIPO Patent Application WO/2023/274367
Kind Code:
A1
Abstract:
A method for preparing a metal organic framework material and the use thereof in the detection of a small molecule. The preparation method comprises: mixing dimethylformamide, ethanol, deionized water, triethylamine and terephthalic acid, adding the mixture to a closed container, and adding metal chloride to form a mixture; performing ultrasonic treatment with a water bath and then centrifuging and washing same; and dispersing the product in deionized water, and separating an ultra-thin metal organic framework material by means of low-speed centrifugation. The metal ion in the metal organic framework material and the thickness thereof can be accurately adjusted, the defect of a traditional matrix is overcome, and a low-sample volume, high-speed, high-throughput and high-sensitivity detection of the small molecule in serum is realized.
Inventors:
QIAN KUN (CN)
CAO JING (CN)
LI SHUNXIANG (CN)
CAO JING (CN)
LI SHUNXIANG (CN)
Application Number:
PCT/CN2022/102857
Publication Date:
January 05, 2023
Filing Date:
June 30, 2022
Export Citation:
Assignee:
UNIV SHANGHAI JIAOTONG (CN)
International Classes:
G01N27/64
Domestic Patent References:
| WO2021007988A1 | 2021-01-21 |
Foreign References:
| CN113484404A | 2021-10-08 | |||
| CN105732728A | 2016-07-06 | |||
| CN112730323A | 2021-04-30 | |||
| CN112295604A | 2021-02-02 | |||
| CN110467731A | 2019-11-19 | |||
| CN103787875A | 2014-05-14 | |||
| CN106512965A | 2017-03-22 |
Attorney, Agent or Firm:
SHANGHAI KESHENG INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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