Title:
PREPARATION OF NOVEL TRITERPENE ALCOHOL DERIVATIVES WITH ENHANCED BIOAVAILABILITY FOR CANCER, INFLAMMATION AND PAIN TREATMENT
Document Type and Number:
WIPO Patent Application WO/2023/147640
Kind Code:
A1
Abstract:
The invention generally refers to pharmaceutical uses of tetracyclic terpene 3-ols, as an example lanosta-8,24-dien-3-ol, bearing polar and/or charged moieties, as anti-inflammatory, anti-cancer and analgesic agents via the inhibition of the disordered activation of serine-threonine protein kinases, particularly PKC.
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Inventors:
PIANOWSKI LUIZ FRANCISCO (BR)
Application Number:
PCT/BR2023/050041
Publication Date:
August 10, 2023
Filing Date:
February 07, 2023
Export Citation:
Assignee:
PIANOWSKI LUIZ FRANCISCO (BR)
GERVASIO ALVES DA SILVA TARSIS (BR)
GERVASIO ALVES DA SILVA TARSIS (BR)
International Classes:
C07J9/00; A61K31/575; A61P29/00; A61P35/00; C07C69/017
Domestic Patent References:
| WO2018137683A1 | 2018-08-02 | |||
| WO2020020306A1 | 2020-01-30 | |||
| WO2020177714A1 | 2020-09-10 | |||
| WO2003027133A1 | 2003-04-03 | |||
| WO2005000866A1 | 2005-01-06 | |||
| WO2015013634A1 | 2015-01-29 | |||
| WO2019104748A1 | 2019-06-06 | |||
| WO2007115181A2 | 2007-10-11 | |||
| WO2006007676A1 | 2006-01-26 | |||
| WO2010015874A1 | 2010-02-11 | |||
| WO2011086424A1 | 2011-07-21 |
Foreign References:
| US20060246124A1 | 2006-11-02 | |||
| JPH0680547A | 1994-03-22 | |||
| JPH04183773A | 1992-06-30 |
Other References:
BILDZIUKEVICH U ET AL.: "Amides derived from heteroaromatic amines and selected steryl hemiesters", STEROIDS, vol. 78, no. 14, 20 December 2013 (2013-12-20), pages 1347 - 52, XP028774953, DOI: 10.1016/j. steroids . 2013.10.00 3
AGGARWAL BABITA; SINGLA RAJEEV K.; ALI MOHD.; SINGH VIJENDER; IGOLI JOHN O.; GUNDAMARAJU ROHIT; KIM KAH HWI: "Triterpenic and monoterpenic esters from stems ofIchnocarpus frutescensand their drug likeness potential", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON., US, vol. 24, no. 4, 19 August 2014 (2014-08-19), US , pages 1427 - 1437, XP035459071, ISSN: 1054-2523, DOI: 10.1007/s00044-014-1227-2
B ILLHEIMER JT ET AL.: "Separation of steryl esters by reversed-phase liquid chromatography", J LIPID RES, vol. 24, no. 12, December 1983 (1983-12-01), pages 1646 - 51, XP055609708
DE SOUZA L S; PUZIOL L C; TOSTA C L; BITTENCOURT M L F; ARDISSON J S; KITAGAWA R R; FILGUEIRAS P R; KUSTER R M: "Analytical methods to access the chemical composition of an Euphorbia tirucalli anticancer latex from traditional Brazilian medicine", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, 1 February 2019 (2019-02-01), IE , pages 255 - 265, XP018535167, ISSN: 0378-8741
SILVA VIVIANE A.; ROSA MARCELA N.; MIRANDA-GONçALVES VERA; COSTA ANGELA M.; TANSINI ALINE; EVANGELISTA ADRIANE F.; MARTINHO O: "Euphol, a tetracyclic triterpene, fromEuphorbia tirucalliinduces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells", INVESTIGATIONAL NEW DRUGS, SPRINGER US, NEW YORK, vol. 37, no. 2, 22 June 2018 (2018-06-22), New York, pages 223 - 237, XP036745350, ISSN: 0167-6997, DOI: 10.1007/s10637-018-0620-y
AGGARWAL BABITA; SINGLA RAJEEV K.; ALI MOHD.; SINGH VIJENDER; IGOLI JOHN O.; GUNDAMARAJU ROHIT; KIM KAH HWI: "Triterpenic and monoterpenic esters from stems ofIchnocarpus frutescensand their drug likeness potential", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON., US, vol. 24, no. 4, 19 August 2014 (2014-08-19), US , pages 1427 - 1437, XP035459071, ISSN: 1054-2523, DOI: 10.1007/s00044-014-1227-2
B ILLHEIMER JT ET AL.: "Separation of steryl esters by reversed-phase liquid chromatography", J LIPID RES, vol. 24, no. 12, December 1983 (1983-12-01), pages 1646 - 51, XP055609708
DE SOUZA L S; PUZIOL L C; TOSTA C L; BITTENCOURT M L F; ARDISSON J S; KITAGAWA R R; FILGUEIRAS P R; KUSTER R M: "Analytical methods to access the chemical composition of an Euphorbia tirucalli anticancer latex from traditional Brazilian medicine", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, 1 February 2019 (2019-02-01), IE , pages 255 - 265, XP018535167, ISSN: 0378-8741
SILVA VIVIANE A.; ROSA MARCELA N.; MIRANDA-GONçALVES VERA; COSTA ANGELA M.; TANSINI ALINE; EVANGELISTA ADRIANE F.; MARTINHO O: "Euphol, a tetracyclic triterpene, fromEuphorbia tirucalliinduces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells", INVESTIGATIONAL NEW DRUGS, SPRINGER US, NEW YORK, vol. 37, no. 2, 22 June 2018 (2018-06-22), New York, pages 223 - 237, XP036745350, ISSN: 0167-6997, DOI: 10.1007/s10637-018-0620-y
Attorney, Agent or Firm:
FERREIRA EVANGELISTA, Katia Jane et al. (BR)
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