Title:
PREPARATION PROCESS FOR ATORVASTATIN AND INTERMEDIATES
Document Type and Number:
WIPO Patent Application WO2003004457
Kind Code:
A3
Abstract:
The invention relates to a novel process for the preparation of 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide and to novel intermediates and process steps therefor. In that process inter alia the intermediate 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide is obtained by nucleophilic substitution from a compound of formula (I), wherein X is a nucleofugal leaving group, with a ketoamide of formula (II) in the presence of a base.
Inventors:
SCHOENING KAI-UWE (CH)
HARTWIG JEMIMA (DE)
HARTWIG JEMIMA (DE)
Application Number:
PCT/EP2002/007014
Publication Date:
March 20, 2003
Filing Date:
June 25, 2002
Export Citation:
Assignee:
CIBA SC HOLDING AG (CH)
SCHOENING KAI-UWE (CH)
HARTWIG JEMIMA (DE)
SCHOENING KAI-UWE (CH)
HARTWIG JEMIMA (DE)
International Classes:
C07C231/12; C07D207/34; C07D405/06; C07C235/78; (IPC1-7): C07C233/07; C07D207/34
Domestic Patent References:
| WO1989007598A2 | 1989-08-24 |
Other References:
BAUMANN K L ET AL: "THE CONVERGENT SYNTHESIS OF CI-981, AN OPTICALLY ACTIVE, HIGHLY POTENT, TISSUE SELECTIVE INHIBITOR OF HMG-COA REDUCTASE", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 33, no. 17, 21 April 1992 (1992-04-21), pages 2283 - 2284, XP000608147, ISSN: 0040-4039
GRAUL A ET AL: "ATORVASTATIN CALCIUM", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 22, no. 9, 1997, pages 956 - 968, XP000904817, ISSN: 0377-8282
GRAUL A ET AL: "ATORVASTATIN CALCIUM", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 22, no. 9, 1997, pages 956 - 968, XP000904817, ISSN: 0377-8282
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