Title:
PREPARATION AND USE OF HIGHLY ACTIVE BLOOD COAGULATION FACTOR XI MUTANT AND GENE THERAPY/EDITING VECTOR AND RECOMBINANT/FUSION PROTEIN THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/114324
Kind Code:
A1
Abstract:
Provided are the preparation and use of a highly active blood coagulation factor XI mutant and a gene therapy/editing vector thereof and a recombinant/fusion protein thereof. The nucleotide sequence of the mutant is as shown in SEQ ID NOs: 1-6, and the amino acid sequence is as shown in SEQ ID NO: 7. The blood coagulation factor XI mutant has a high blood coagulation activity, can activate a blood coagulation reaction and improve the body's overall blood coagulation function, can be used in the treatment of hemorrhagic diseases, and has good prospects in gene therapy, gene editing and recombinant protein replacement therapy.
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Inventors:
WANG XUEFENG (CN)
WU WENMAN (CN)
DING QIULAN (CN)
WU WENMAN (CN)
DING QIULAN (CN)
Application Number:
PCT/CN2018/103201
Publication Date:
June 20, 2019
Filing Date:
August 30, 2018
Export Citation:
Assignee:
RUIJIN HOSPITAL SHANGHAI JIAOTONG UNIV SCHOOL MEDICINE (CN)
WANG XUEFENG (CN)
WU WENMAN (CN)
DING QIULAN (CN)
WANG XUEFENG (CN)
WU WENMAN (CN)
DING QIULAN (CN)
International Classes:
A61K38/48; C12N9/64; A61K48/00; A61P7/04; C12N15/57; C12N15/85
Domestic Patent References:
| WO2016207858A1 | 2016-12-29 |
Foreign References:
| CN108220274A | 2018-06-29 | |||
| CN102559720A | 2012-07-11 |
Other References:
WIEWEL-VERSCHUEREN, SOPHIE: "Factor 11 single-nucleotide variants in women with heavy menstrual bleeding", J OBSTET GYNAECOL., vol. 37, no. 7, 13 June 2017 (2017-06-13), pages 912 - 918, XP055617557, ISSN: 1364-6893
Attorney, Agent or Firm:
SHANGHAI TECHNOVO INTELLECTUAL PROPERTY AGENT FIRM (CN)
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