Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PREPARATION AND USE OF MOLECULAR SITE TARGETED AND ACTIVATED KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2018/133766
Kind Code:
A1
Abstract:
Disclosed are a preparation and a use of a molecular site targeted and activated kinase inhibitor. Specifically, disclosed is a compound represented by the following formula: Lactobionic acid residue -XAN-PABC-Z or a pharmaceutically acceptable salt thereof. In the formula, X is a polar and non-polar uncharged amino acid such as alanine, valine, or threonine, A is alanine, N is asparagine, PABC is -NH-phenyl-CH2-O-, and Z is a drug molecule, wherein a lactobionic acid residue, XAN, and PABC are linked to each other by an amide bond, and PABC and Z are linked by an ester group, namely, -O-C(O)-.

Inventors:
LIU YUAN (CN)
LIU CHENG (CN)
WANG HAIYANG (CN)
Application Number:
CN2018/072766
Publication Date:
July 26, 2018
Filing Date:
January 16, 2018
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
YAFEI SHANGHAI BIOLOG MEDICINE SCIENCE & TECH CO LTD (CN)
International Classes:
C07K5/083; A61K31/44; A61P35/00; A61P35/02; A61P35/04; C07D213/81
Domestic Patent References:
WO2004113274A22004-12-29
WO2016026458A12016-02-25
Foreign References:
CN105792850A2016-07-20
US20080019918A12008-01-24
CN106344930A2017-01-25
Other References:
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
Download PDF: