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Title:
PREPARATION AND USE OF MOLECULAR SITE TARGETED AND ACTIVATED KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2018/133766
Kind Code:
A1
Abstract:
Disclosed are a preparation and a use of a molecular site targeted and activated kinase inhibitor. Specifically, disclosed is a compound represented by the following formula: Lactobionic acid residue -XAN-PABC-Z or a pharmaceutically acceptable salt thereof. In the formula, X is a polar and non-polar uncharged amino acid such as alanine, valine, or threonine, A is alanine, N is asparagine, PABC is -NH-phenyl-CH2-O-, and Z is a drug molecule, wherein a lactobionic acid residue, XAN, and PABC are linked to each other by an amide bond, and PABC and Z are linked by an ester group, namely, -O-C(O)-.

Inventors:
LIU, Yuan (Room 302, No. 46 Lane 1688, Landian Road, Shanghai 3, 201203, CN)
LIU, Cheng (Room 2102, No. 22 Lane 1299, Dingxiang Road,Pudong New Area, Shanghai 0, 201210, CN)
WANG, Haiyang (Room 401, No. 34 Lane 2195, Zhongke Road,Pudong New Area, Shanghai 0, 201210, CN)
Application Number:
CN2018/072766
Publication Date:
July 26, 2018
Filing Date:
January 16, 2018
Export Citation:
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Assignee:
YAFEI SHANGHAI BIOLOG MEDICINE SCIENCE & TECHNOLOGY CO.LTD. (N Room, 4 Floor No.780 Cai Lun Road, Zhangjiang High-tech park,Pudong District, Shanghai 3, 201203, CN)
International Classes:
C07K5/083; A61K31/44; A61P35/00; A61P35/02; A61P35/04; C07D213/81
Domestic Patent References:
WO2004113274A22004-12-29
WO2016026458A12016-02-25
Foreign References:
CN105792850A2016-07-20
US20080019918A12008-01-24
CN106344930A2017-01-25
Other References:
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (435 Guiping Road, Shanghai 3, 200233, CN)
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