Title:
PREPARATION AND USE OF REACTIVE OXYGEN SPECIES SCAVENGER
Document Type and Number:
WIPO Patent Application WO/2019/041361
Kind Code:
A1
Abstract:
A compound of Formula (I), pharmaceutically acceptable salts thereof, and individual enantiomers or diastereomers thereof are disclosed. Compositions and methods useful for treatment or suppression of diseases, developmental delays and symptoms related to oxidative stress are also disclosed.
Inventors:
XIANG JIA-NING (CN)
QI ZUDE (CN)
NING DEZHENG (CN)
LIU XIANBO (CN)
QI ZUDE (CN)
NING DEZHENG (CN)
LIU XIANBO (CN)
Application Number:
PCT/CN2017/100431
Publication Date:
March 07, 2019
Filing Date:
September 04, 2017
Export Citation:
Assignee:
XW LAB INC (GB)
XW LAB INC (GB)
XW LAB INC (GB)
International Classes:
C07K5/02; A61K38/07; A61K38/08; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C07K7/02
Domestic Patent References:
| WO2012068081A1 | 2012-05-24 |
Foreign References:
| CN106866784A | 2017-06-20 |
Other References:
WIPF, PETER ET AL.: "Mitochondrial Targeting of Selective Electron Scavengers: Synthesis and Biological Analysis of Hemigramicidin-TEMPO Conjugates", J. AM. CHEM. SOC., vol. 127, 19 August 2005 (2005-08-19), pages 12460 - 12461, XP055018693, DOI: doi:10.1021/ja053679l
JIANG, JIANFEI ET AL.: "Structural Requirements for Optimized Delivery, Inhibition of Oxidative Stress, and Antiapoptotic Activity of Targeted Nitroxides", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 320, no. 3, 31 December 2007 (2007-12-31), pages 1050 - 1060, XP009095061, DOI: doi:10.1124/jpet.106.114769
KRAINZ, TANJA ET AL.: "A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis", ACS CENTRAL SCIENCE, vol. 2, no. 9, 28 September 2016 (2016-09-28), pages 653 - 659, XP055581175
JIANG, JIANFEI ET AL.: "Structural Requirements for Optimized Delivery, Inhibition of Oxidative Stress, and Antiapoptotic Activity of Targeted Nitroxides", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 320, no. 3, 31 December 2007 (2007-12-31), pages 1050 - 1060, XP009095061, DOI: doi:10.1124/jpet.106.114769
KRAINZ, TANJA ET AL.: "A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis", ACS CENTRAL SCIENCE, vol. 2, no. 9, 28 September 2016 (2016-09-28), pages 653 - 659, XP055581175
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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