Title:
PREPARATION AND USE OF RECOMBINANT MULTICOMPONENT SARS-COV-2 TRIMERIC PROTEIN VACCINE CAPABLE OF INDUCING BROAD-SPECTRUM NEUTRALIZING ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2023/160654
Kind Code:
A1
Abstract:
The present invention relates to the field of molecular vaccinology. Provided in the present invention is a recombinant multicomponent SARS-CoV-2 trimeric protein vaccine capable of inducing a broad-spectrum neutralizing activity. Recombinant protein ingredients include, but are not limited to, homotrimeric proteins formed by means of introducing mutation sites and trimeric auxiliary structures to the extracellular domains (ECD) of spike proteins (S proteins) of Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2) and BA.1 (B.1.1.529.1). The multicomponent vaccine contains an ECD trimeric protein of the above variants, either alone or in any combination, and a pharmaceutically acceptable adjuvant. The vaccine combination shows excellent immunogenicity in mice, while also maintaining long-term humoral immunity and cellular immune responses. The multicomponent SARS-CoV-2 trimeric protein vaccine can be used for preventing infection-related diseases caused by infections with SARS-CoV-2 and variants thereof.
More Like This:
Inventors:
XIE LIANGZHI (CN)
SUN CHUNYUN (CN)
ZHANG YANJING (CN)
SUN CHUNYUN (CN)
ZHANG YANJING (CN)
Application Number:
PCT/CN2023/078135
Publication Date:
August 31, 2023
Filing Date:
February 24, 2023
Export Citation:
Assignee:
SINOCELLTECH LTD (CN)
International Classes:
C07K19/00; A61K39/215; A61P11/00; A61P31/14; C07K14/165; C12N7/01; C12N15/50
Domestic Patent References:
| WO2021204825A2 | 2021-10-14 |
Foreign References:
| CN113388041A | 2021-09-14 | |||
| CN112552380A | 2021-03-26 | |||
| US11225508B1 | 2022-01-18 |
Other References:
XUN WANG, WANG PENGFEI: "Advances in Vaccine Research against Novel Coronavirus Mutant Strains", ZHANGJIANG TECHNOLOGY REVIEW, vol. 6, 28 December 2021 (2021-12-28), pages 35 - 37, XP093088284
MALIK, J.A.: "Targets and Strategies for Vaccine Development against SARS-CoV-2", BIOMEDICINE & PHARMACOTHERAPY, vol. 137, 31 May 2021 (2021-05-31)
PINGPING JIANG, WANG TING: "SARS-CoV-2 immunity and vaccine progress ", CHINESE JOURNAL OF PHARMACEUTICS(ON LINE), vol. 20, no. 1, 15 January 2022 (2022-01-15), pages 40 - 46, XP093088303, DOI: 10.14146/j.cnki.cjp.2022.01.004
MALIK, J.A.: "Targets and Strategies for Vaccine Development against SARS-CoV-2", BIOMEDICINE & PHARMACOTHERAPY, vol. 137, 31 May 2021 (2021-05-31)
PINGPING JIANG, WANG TING: "SARS-CoV-2 immunity and vaccine progress ", CHINESE JOURNAL OF PHARMACEUTICS(ON LINE), vol. 20, no. 1, 15 January 2022 (2022-01-15), pages 40 - 46, XP093088303, DOI: 10.14146/j.cnki.cjp.2022.01.004
Attorney, Agent or Firm:
RUNPING & PARTNERS (CN)
Download PDF:
Previous Patent: NON-ARCHED RAINPROOF WATER COLLECTION GREENHOUSE
Next Patent: COMMUNICATION METHOD AND APPARATUS
Next Patent: COMMUNICATION METHOD AND APPARATUS