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Title:
PREPARATION OF ZINC LINOLEATE, AND APPLICATION THEREOF IN PREPARING ANTI-HELICOBACTER PYLORI DRUG
Document Type and Number:
WIPO Patent Application WO/2019/219093
Kind Code:
A3
Abstract:
A preparation of zinc linoleate, and an application thereof in preparing an anti-helicobacter pylori drug. Zinc chloride is dissolved in sterile water, and the zinc chloride solution is heated and activated in a reactor, then naturally cooled to room temperature; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxysulfosuccinimide sodium salt and linolenic acid are dissolved in EMS solvent and activated in nitrogen gas; the activated zinc chloride and the activated linolenic acid are heated and reacted, then left to cool after the reaction is finished; a dialysis bag is used to perform dialysis in pure water until the pure water is clear and transparent; a vacuum freeze dryer is used to perform drying, and zinc linoleate is obtained. The present invention successfully prepares zinc linoleate, the yield is high, and the zinc linoleate has a good helicobacter pylori inhibiting effect.

Inventors:
BI HONGKAI (CN)
HUANG YANQIANG (CN)
HANG XUDONG (CN)
ZENG LIPING (CN)
JIA JIA (CN)
Application Number:
CN2019/094664
Publication Date:
December 19, 2019
Filing Date:
July 04, 2019
Export Citation:
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Assignee:
UNIV NANJING MEDICAL (CN)
International Classes:
C07C51/41; A61K31/202; A61P31/04; C07C57/12
Foreign References:
CN108623448A2018-10-09
CN1837177A2006-09-27
GB2217602A1989-11-01
Other References:
HUANG, YANQIANG ET AL.: "In vitro and in vivo activities of zinc linolenate, a selective antibacterial agent against Helicobacter pylori", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1 April 2019 (2019-04-01), XP055673168
HUANG, YANQIANG: "In vitro and in vivo activities of zinc linolenate, a selective antibacterial agent against Helicobacter pylori", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 63, no. 6, 1 April 2019 (2019-04-01), XP055673168
HUANG, YANQIANG ET AL.: "The Antibacterial Activity of Zinc Linolenic Acid Small Molecular Compounds to Helicobacter Pylori", PROCEEDINGS OF THE 13TH CHINA ANTIBIOTICS CONFERENCE, 22 November 2017 (2017-11-22), pages 264
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD (CN)
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