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Title:
PRETREATING AGENT FOR ANTITHROMBIN III FOR USE IN LIMULUS TEST, AND PRETREATMENT METHOD
Document Type and Number:
WIPO Patent Application WO/2014/104352
Kind Code:
A1
Abstract:
Provided is a means for diminishing the reaction interference which antithrombin III causes when used in a limulus test and for thereby enabling the limulus test with the antithrombin III to be carried out with high accuracy. Antithrombin III which is to be used in a limulus test is subjected to a treatment for protein deactivation in the presence of a salt of a divalent metal, thereby diminishing the reaction interference which the antithrombin III may cause when used in the limulus test.

Inventors:
AIZAWA MAKI (JP)
ODA TOSHIO (JP)
AKETAGAWA JUN (JP)
Application Number:
PCT/JP2013/085234
Publication Date:
July 03, 2014
Filing Date:
December 27, 2013
Export Citation:
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Assignee:
SEIKAGAKU KOGYO CO LTD (JP)
International Classes:
G01N33/48; G01N33/579; C07K5/103
Domestic Patent References:
WO2006080448A12006-08-03
WO2006080448A12006-08-03
WO2005035563A12005-04-21
WO2012118226A12012-09-07
Foreign References:
JP2005308574A2005-11-04
JPH09178753A1997-07-11
JPH06130064A1994-05-13
JP2004109147A2004-04-08
JP2010243342A2010-10-28
JPH04102064A1992-04-03
JPH0670796A1994-03-15
JP2010243342A2010-10-28
Other References:
See also references of EP 2940468A4
"Endotoxin and Natural Immunity Research 15 -Rapidly Developing Natural Immunity Research", 2012, IGAKUTOSHO-SHUPPAN LTD., pages: 27 - 30
"Endotoxin Research 12 - New Development in Natural Immunity Research", 2009, IGAKUTOSHO-SHUPPAN LTD., pages: 93 - 97
NAKAMURA T. ET AL., J. BIOCHEM., vol. 99, no. 3, March 1986 (1986-03-01), pages 847 - 57
MIYATA ET AL., PROTEIN NUCLEIC ACID ENZYME, EXTRA ISSUE, NO. 29, 1986, pages 30 - 43
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
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