Title:
PREVENTING DESENSITIZATION OF RECEPTORS
Document Type and Number:
WIPO Patent Application WO2004039313
Kind Code:
A3
Abstract:
Desensitization of receptors that control disease is prevented by inhibiting G-protein receptor kinases. This has applicability, e.g., for patients with heart failure or on a left ventricular heart device or a heart pump after surgery or about to undergo surgery and at high risk for a cardiac event or on an opiate or addicted to opiate or with cystic fibrosis or rheumatoid arthritis.
Inventors:
STAMLER JONATHAN S
LEFKOWITZ ROBERT J
WHALEN ERIN J
KOCH WALTER J
PIANTADOSI CLAUDE A
LEFKOWITZ ROBERT J
WHALEN ERIN J
KOCH WALTER J
PIANTADOSI CLAUDE A
Application Number:
PCT/US2003/029134
Publication Date:
July 22, 2004
Filing Date:
October 20, 2003
Export Citation:
Assignee:
UNIV DUKE (US)
International Classes:
A61K31/19; A61K31/195; A61K31/198; A61K31/21; A61K31/223; A61K45/00; A61K31/5377; A61K38/00; A61K38/05; A61K38/06; A61P1/00; A61P7/00; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P11/06; A61P19/02; A61P21/00; A61P25/00; A61P25/22; A61P25/24; A61K; (IPC1-7): A61K38/00; A61P19/02; A61P9/00; A61P9/04; A61P9/14; A61P9/10
Foreign References:
| US6627602B2 | 2003-09-30 | |||
| US20030212004A1 | 2003-11-13 | |||
| US20020128205A1 | 2002-09-12 | |||
| US6472390B1 | 2002-10-29 | |||
| US5385937A | 1995-01-31 |
Other References:
NOZIK-GRAYCK ET AL: "Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione", AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELL MOL PHYSIOLOGY, vol. 282, 2002, pages L1057 - L1065, XP002977051
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