Title:
PREVENTING PATHOLOGICAL INCREASES IN THE RATE OF NERVE CELL SUICIDE IN IMMATURE NERVOUS SYSTEMS
Document Type and Number:
WIPO Patent Application WO2006017524
Kind Code:
A3
Abstract:
A method for preventing pediatric and obstetric medical drugs from triggering apoptotic neurodegeneration in an immature nervous system is disclosed. The method comprises coadministration of (1) a drug that has been shown in in vivo tests to trigger apoptotic neurodegeneration in unprotected neonatal mammals and (2) a drug the enters the mammalian central nervous system and stimulates neuronal activity to prevent neuroapoptosis. Examples of the first group of drugs include drugs that suppress activity at the NMDA subclass of glutamate receptors and promote inhibitory transmission through at least one class of GABA receptors. Examples of the second drug include, lithium and xenon.
More Like This:
Inventors:
OLNEY JOHN W (US)
Application Number:
PCT/US2005/027460
Publication Date:
August 31, 2006
Filing Date:
August 02, 2005
Export Citation:
Assignee:
OLNEY JOHN W (US)
International Classes:
A01N43/50; A01N35/06; A01N47/28; A01N59/00; A01N59/08; A61K31/02
Foreign References:
| US6559190B1 | 2003-05-06 | |||
| US20030180375A1 | 2003-09-25 | |||
| US20040028656A1 | 2004-02-12 |
Other References:
OLNEY J.W. ET AL.: "Do Pediatric Drugs Cause Developing Neurons to Commit Suicide?", TRENDS IN PHARMACEUTICAL SCIENCES, vol. 25, no. 3, March 2004 (2004-03-01), pages 135 - 139, XP004493460
BITTIGAU P. ET AL.: "Antiepileptic Drugs and Apoptotic Neurodegeneration in the Developing Brain", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 23, November 2002 (2002-11-01), pages 15089 - 15094, XP003003654
JEVTOVIC-TODOROVIC V. ET AL.: "Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits", JOURNAL OF NEUROSCIENCE, vol. 23, no. 3, February 2003 (2003-02-01), pages 876 - 882, XP002353922
BITTIGAU P. ET AL.: "Antiepileptic Drugs and Apoptotic Neurodegeneration in the Developing Brain", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 23, November 2002 (2002-11-01), pages 15089 - 15094, XP003003654
JEVTOVIC-TODOROVIC V. ET AL.: "Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits", JOURNAL OF NEUROSCIENCE, vol. 23, no. 3, February 2003 (2003-02-01), pages 876 - 882, XP002353922
Download PDF:
Previous Patent: APPLICATIONS WITH INTEGRATED CAPTURE
Next Patent: STUB OUT FLUID QUICK CONNECTOR WITH SHUT OFF VALVE INTERFACE
Next Patent: STUB OUT FLUID QUICK CONNECTOR WITH SHUT OFF VALVE INTERFACE