Title:
PREVENTION OF NEURODEGENERATION BY MACROLIDE ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO2007022076
Kind Code:
A9
Abstract:
The present disclosure describes the use of macrolide antibiotics to prevent neurodegeneration and to treat or prevent disease and conditions which involve neurodegeneration. While not being limited to a specific mechanism of action, in one embodiment, the macrolide antibiotics inhibit neurodegeneration caused by lysosomal and/or mitochondrial dysfunction. The present disclosure contemplates the use of any macrolide antibiotic and pharmaceutically acceptable derivatives thereof. In a specific embodiment, the macrolide antibiotics include bafilomycin A1, bafilomycin B1 and concanamycin.
Inventors:
SHACKA JOHN J (US)
ROTH KEVIN A (US)
ROTH KEVIN A (US)
Application Number:
PCT/US2006/031619
Publication Date:
May 29, 2008
Filing Date:
August 14, 2006
Export Citation:
Assignee:
UAB RESEARCH FOUNDATION (US)
SHACKA JOHN J (US)
ROTH KEVIN A (US)
SHACKA JOHN J (US)
ROTH KEVIN A (US)
International Classes:
A01N43/04; A61K31/70
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