Title:
PREVENTION AND TREATMENT OF ANEURYSMS USING PPARγ INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2011/007565
Kind Code:
A1
Abstract:
Disclosed is a prophylactic and/or therapeutic drug for aneurysms which comprises a PPARγ inhibitor as the active ingredient. It was discovered that a circulatory failure within the vascular wall cause the fibroblasts constituting abdominal aortic aneurysmal adventitia to express PPARγ and differentiate into adipocyte-like cells, which induces the abnormal accumulation of triglycerides in the vascular wall and weakens the vascular wall. The PPARγ inhibitor comprehensively corrects these factors to prevent the onset, progression and rupture of aneurysms. Thus, the life prognosis of patients with aneurysms can be improved.
Inventors:
SETOU MITSUTOSHI (JP)
ZAIMA NOBUHIRO (JP)
UNNO NAOKI (JP)
TANAKA HIROKI (JP)
ZAIMA NOBUHIRO (JP)
UNNO NAOKI (JP)
TANAKA HIROKI (JP)
Application Number:
PCT/JP2010/004570
Publication Date:
January 20, 2011
Filing Date:
July 14, 2010
Export Citation:
Assignee:
NAT UNIVERSITY CORP HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE (JP)
SETOU MITSUTOSHI (JP)
ZAIMA NOBUHIRO (JP)
UNNO NAOKI (JP)
TANAKA HIROKI (JP)
SETOU MITSUTOSHI (JP)
ZAIMA NOBUHIRO (JP)
UNNO NAOKI (JP)
TANAKA HIROKI (JP)
International Classes:
A61K45/00; A61P9/10
Other References:
YASUNARI SAKOMURA ET AL.: "Daidomyaku Nojo Chumaku Hensei ni Kansuru Bunshi Byori Soshikigakuteki Kenkyu -Daidomyakuryu.Kairi no Yakubutsuteki Yoboho no Kaihatsu", JAPAN RESEARCH PROMOTION SOCIETY FOR CARDIOVASCULAR DISEASE KENKYU GYOSEKISHU, no. 18, 2003, pages 19 - 22
YE, F. ET AL.: "The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation", CHEMBIOCHEM, vol. 7, no. 1, 2006, pages 74 - 82
DENG, G. ET AL.: "Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling", EUR J MED CHEM, vol. 43, no. 12, 2008, pages 2699 - 2716, XP025714716, DOI: doi:10.1016/j.ejmech.2008.01.032
YE, F. ET AL.: "The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation", CHEMBIOCHEM, vol. 7, no. 1, 2006, pages 74 - 82
DENG, G. ET AL.: "Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling", EUR J MED CHEM, vol. 43, no. 12, 2008, pages 2699 - 2716, XP025714716, DOI: doi:10.1016/j.ejmech.2008.01.032
Attorney, Agent or Firm:
OHNO, Seiji et al. (JP)
Seiji Ono (JP)
Seiji Ono (JP)
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