Title:
PREVENTION OR TREATMENT OF ANEURYSMS USING MIR-33B INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/177267
Kind Code:
A1
Abstract:
A prophylactic or therapeutic agent for aneurysms that comprises, as an active ingredient, a miR-33b inhibitor, preferably an antisense oligonucleotide against miR-33b.
Inventors:
KOTERA JUN (JP)
ONO KOH (JP)
HORIE TAKAHIRO (JP)
YAMASAKI TOMOHIRO (JP)
KOYAMA SATOSHI (JP)
OBIKA SATOSHI (JP)
KASAHARA YUYA (JP)
ONO KOH (JP)
HORIE TAKAHIRO (JP)
YAMASAKI TOMOHIRO (JP)
KOYAMA SATOSHI (JP)
OBIKA SATOSHI (JP)
KASAHARA YUYA (JP)
Application Number:
PCT/JP2021/007822
Publication Date:
September 10, 2021
Filing Date:
March 02, 2021
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
UNIV KYOTO (JP)
UNIV OSAKA (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
UNIV KYOTO (JP)
UNIV OSAKA (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
International Classes:
A61K45/00; A61K31/7105; A61K31/711; A61K31/7115; A61K31/712; A61K31/7125; A61K31/713; A61P9/10; C12N15/113
Domestic Patent References:
| WO2009006478A2 | 2009-01-08 | |||
| WO2008150729A2 | 2008-12-11 | |||
| WO2008154401A2 | 2008-12-18 | |||
| WO2011052436A1 | 2011-05-05 |
Foreign References:
| JP2012522509A | 2012-09-27 | |||
| JP2009532392A | 2009-09-10 | |||
| US7399845B2 | 2008-07-15 | |||
| US20040171570A1 | 2004-09-02 | |||
| US7427672B2 | 2008-09-23 |
Other References:
HARTLEY EMMA L, SANDERSON BARNABY, VASQUES FRANCESCO, DALY KATHLEEN JR, LOZINSKI MARIA, BARRETT NICHOLAS A, CAMPOROTA LUIGI: "miR-33-5p knockdown attenuates abdominal aortic aneurysm progression via promoting target adenosine triphosphate-binding cassette transporter A1 expression and activating the PI3K/Akt signaling pathway", PERFUSION, vol. 35, no. 1, 1 May 2020 (2020-05-01), pages 57 - 65, XP055852506
NISHINO TOMOHIRO, HORIE TAKAHIRO, BABA OSAMU, SOWA NAOYA, HANADA RITSUKO, KUWABARA YASUHIDE, NAKAO TETSUSHI, NISHIGA MASATAKA, NIS: "SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 38, no. 10, 26 July 2018 (2018-07-26), pages 2460 - 2473, XP055852507
THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 99, 2010, pages 237 - 244
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
ZHANGMADDEN, GENOME RES, vol. 7, 1997, pages 649 - 656
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482 - 489
CHATTOPADHYAYA ET AL., J. ORG. CHEM., vol. 74, 2009, pages 118 - 134
PROC. NATL. ACAD. SCI.USA, vol. 113, no. 21, 2016, pages 5898 - 903
MOL. PHARM., vol. 16, no. 2, 2019, pages 914 - 920
J. AM. CHEM. SOC., vol. 139, no. 9, 2017, pages 3446 - 3455
ATHEROSCLEROSIS, vol. 226, 2013, pages 29 - 39
See also references of EP 4129338A4
NISHINO TOMOHIRO, HORIE TAKAHIRO, BABA OSAMU, SOWA NAOYA, HANADA RITSUKO, KUWABARA YASUHIDE, NAKAO TETSUSHI, NISHIGA MASATAKA, NIS: "SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 38, no. 10, 26 July 2018 (2018-07-26), pages 2460 - 2473, XP055852507
THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 99, 2010, pages 237 - 244
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
ZHANGMADDEN, GENOME RES, vol. 7, 1997, pages 649 - 656
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482 - 489
CHATTOPADHYAYA ET AL., J. ORG. CHEM., vol. 74, 2009, pages 118 - 134
PROC. NATL. ACAD. SCI.USA, vol. 113, no. 21, 2016, pages 5898 - 903
MOL. PHARM., vol. 16, no. 2, 2019, pages 914 - 920
J. AM. CHEM. SOC., vol. 139, no. 9, 2017, pages 3446 - 3455
ATHEROSCLEROSIS, vol. 226, 2013, pages 29 - 39
See also references of EP 4129338A4
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
Download PDF: