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Title:
PREVENTIVE OR REMEDY FOR INCREASED URINARY FREQUENCY AND URINARY INCONTINENCE
Document Type and Number:
WIPO Patent Application WO/2007/083640
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a drug which has a selective β3 receptor activating effect and is useful in preventing or treating increased urinary frequency and urinary incontinence. [MEANS FOR SOLVING PROBLEMS] It is disclosed that 6-[2-(R)-[(2-[(R)-(3-chlorophenyl)-2-hydroxyethyl)amino]propyl]-2,3-dihydro-1,4-benzodioxy-2-(R)-carboxylic acid or a pharmacologically acceptable salt thereof is efficacious in preventing and treating increased urinary frequency and urinary incontinence, in particular, increased urinary frequency and urinary incontinence caused by hyperactive bladder.

Inventors:
KURATA RYUICHI (JP)
NAKAZAWA SAYAKO (JP)
Application Number:
PCT/JP2007/050550
Publication Date:
July 26, 2007
Filing Date:
January 17, 2007
Export Citation:
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Assignee:
KYORIN SEIYAKU KK (JP)
NISSIN PHARMA INC (JP)
KURATA RYUICHI (JP)
NAKAZAWA SAYAKO (JP)
International Classes:
A61K31/357; A61P13/02; A61P13/10; C07D319/20
Domestic Patent References:
WO2003106418A12003-12-24
WO1997015549A11997-05-01
WO2000002846A12000-01-20
WO1998007445A11998-02-26
Foreign References:
JPH1112171A1999-01-19
Other References:
YAMAZAKI Y. ET AL.: "Shinki beta3-Adrenalin Juyotai Sadoyaku KUC-7483 no Kakatsudo Boko Chiryoyaku to shite no Kenyu", NEUROGENIC BLADDER SOCIETY KAISHI, vol. 15, no. 1, 2004, pages 71, XP003015466
YANAGISAWA T. ET AL.: "Selectivity and potency of agonists for the three subtypes of cloned human b-adrenoceptors expressed in Chinese hamster ovary cells", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, vol. 192, no. 3, 2000, pages 181 - 193, XP003015467
Attorney, Agent or Firm:
MIZUNO, Katsufumi et al. (2-3 Marunouchi 2-chom, Chiyoda-ku Tokyo 05, JP)
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