Title:
PREVENTIVE OR THERAPEUTIC AGENT FOR DISEASE CAUSED BY DECREASE IN LACRIMAL FLUID
Document Type and Number:
WIPO Patent Application WO/2007/026630
Kind Code:
A1
Abstract:
It is intended to provide a preventive or therapeutic drug for a disease caused by a decrease in lacrimal fluid. More specifically, it is intended to provide a preventive or therapeutic drug for a disease caused by a decrease in lacrimal fluid (dry eye, dry keratoconjunctivitis, keratoconjunctival epithelial damage, a decrease in lacrimation, xerophthalmia, age-related dry eye syndrome, eye damage in Stevens-Johnson syndrome, eye damage in Sjogren syndrome, keratoconjunctival ulcer, dryness in wearing contact lenses or the like), characterized by containing a β3-adrenergic receptor stimulant. Further, it is intended to provide a combination drug, characterized by containing the β3-adrenergic receptor stimulant and a β2-adrenergic receptor stimulant in combination.
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Inventors:
KOBAYASHI MAMORU (JP)
ASARI TETSUYA (JP)
ASARI TETSUYA (JP)
Application Number:
PCT/JP2006/316836
Publication Date:
March 08, 2007
Filing Date:
August 28, 2006
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
KOBAYASHI MAMORU (JP)
ASARI TETSUYA (JP)
KOBAYASHI MAMORU (JP)
ASARI TETSUYA (JP)
International Classes:
A61K31/137; A61K45/00; A61K31/195; A61K31/216; A61K31/472; A61P27/02; A61P43/00
Domestic Patent References:
| WO2004072016A1 | 2004-08-26 | |||
| WO2004072016A1 | 2004-08-26 | |||
| WO2001041806A1 | 2001-06-14 | |||
| WO1999005090A1 | 1999-02-04 |
Foreign References:
| EP1002791A1 | 2000-05-24 | |||
| EP1095932A1 | 2001-05-02 | |||
| EP1153614A1 | 2001-11-14 |
Other References:
HOFFSTEDT J. ET AL.: "Effects of several putative beta3-adrenoceptor agonists on lipolysis in human omental adipocytes", INT. J. OBES. RELAT. METAB. DISORD., vol. 20, no. 5, 1996, pages 428 - 434, XP003002946
JUN SHIMAZAKI ET AL., GANKA (OPHTHALMOLOGY, vol. 37, 1995, pages 765 - 770
"Dry eye clinic", 2000, pages: 43 - 53
"Ocular Surface no Shindan to Chiryo (Diagnosis and Treatment of Ocular Surface", 1993, MEDICAL AOI PUBLICATION, pages: 15 - 30
LEMP M.A. ET AL.: "The lacrimal apparatus. Adler's physiology of the eye", 1992, MOSBY YEAR BOOK COMPANY, pages: 18 - 28
PETOUNIS A.D. ET AL., INT. OPHTHALM., vol. 13, 1989, pages 75 - 80
SULLIVAN D.A. ET AL.: "Lacrimal grand, tear film and dry eye syndromes", 1994, PLENUM PRESS COMPANY, pages: 1 - 9
"NEW Yakurigaku (New pharmacology", 2002, pages: 227 - 236
See also references of EP 1938837A4
JUN SHIMAZAKI ET AL., GANKA (OPHTHALMOLOGY, vol. 37, 1995, pages 765 - 770
"Dry eye clinic", 2000, pages: 43 - 53
"Ocular Surface no Shindan to Chiryo (Diagnosis and Treatment of Ocular Surface", 1993, MEDICAL AOI PUBLICATION, pages: 15 - 30
LEMP M.A. ET AL.: "The lacrimal apparatus. Adler's physiology of the eye", 1992, MOSBY YEAR BOOK COMPANY, pages: 18 - 28
PETOUNIS A.D. ET AL., INT. OPHTHALM., vol. 13, 1989, pages 75 - 80
SULLIVAN D.A. ET AL.: "Lacrimal grand, tear film and dry eye syndromes", 1994, PLENUM PRESS COMPANY, pages: 1 - 9
"NEW Yakurigaku (New pharmacology", 2002, pages: 227 - 236
See also references of EP 1938837A4
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