Title:
PREVENTIVE OR THERAPEUTIC AGENT FOR IDIOPATHIC INFLAMMATORY MYOPATHY
Document Type and Number:
WIPO Patent Application WO/2013/140787
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel preventive or therapeutic agent to prevent/treat idiopathic inflammatory myopathy effectively and safely. An antibody or an antibody fragment which specifically binds to DNAM-1 and does not bind to an Fc receptor is used as the active ingredient of the preventive or therapeutic agent for idiopathic inflammatory myopathy. More specifically, an F(ab')2 antibody produced by isolating the F(ab')2 part from an anti DNAM-1 antibody is used as the active ingredient of the preventive or therapeutic agent for idiopathic inflammatory myopathy.
Inventors:
KOHSAKA HITOSHI (JP)
SHIBUYA AKIRA (JP)
SHIBUYA AKIRA (JP)
Application Number:
PCT/JP2013/001864
Publication Date:
September 26, 2013
Filing Date:
March 19, 2013
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MED & DENT (JP)
UNIV TSUKUBA (JP)
UNIV TSUKUBA (JP)
International Classes:
A61K39/395; A61K39/44; A61P17/00; A61P21/00; A61P29/00
Domestic Patent References:
| WO2007116945A1 | 2007-10-18 |
Other References:
TAHARA-HANAOKA, S. ET AL.: "Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor", BLOOD, vol. 107, no. 4, 2006, pages 1491 - 1496, XP003018250, DOI: doi:10.1182/blood-2005-04-1684
KOJIMA, H. ET AL.: "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells", J BIOL CHEM, vol. 278, no. 38, 2003, pages 36748 - 36753
SHRESTHA, S. ET AL.: "Untreated Juvenile Dermatomyositis: Altered Peripheral Blood Natural Killer Cell Receptors Associated with Increased Natural Killer Cell Localization in Inflamed Muscle", ARTHRITIS & RHEUMATISM, vol. 63, no. 10, 2011, pages S388
KOJIMA, H. ET AL.: "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells", J BIOL CHEM, vol. 278, no. 38, 2003, pages 36748 - 36753
SHRESTHA, S. ET AL.: "Untreated Juvenile Dermatomyositis: Altered Peripheral Blood Natural Killer Cell Receptors Associated with Increased Natural Killer Cell Localization in Inflamed Muscle", ARTHRITIS & RHEUMATISM, vol. 63, no. 10, 2011, pages S388
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
Masaki Hirota (JP)
Masaki Hirota (JP)
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