Title:
PREVENTIVE AND/OR THERAPEUTIC AGENTS FOR BRONCHIAL ASTHMA
Document Type and Number:
WIPO Patent Application WO/2005/011674
Kind Code:
A1
Abstract:
Preventive and/or therapeutic agents for bronchial asthma and tachykinin inhibitors, containing as the active ingredient tricyclic compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R1 is hydrogen, halogeno, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower alkoxy; X1-X2-X3 is CR5=CR6-CR7=CR8 (wherein R5, R6, R7 and R8 are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like) or the like; Y is -CH2S-, -CH2SO-, -CH2SO2-, -CH2O-, -CH=CH-, -(CH2)p- (wherein p is an integer of 0 to 2), -SCH2-, -SOCH2-, -SO2CH2-, or -OCH2-; and R2 is hydrogen, substituted or unsubstituted lower alkyl, or the like.
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Inventors:
IKEMURA TOSHIHIDE
KARASAWA AKIRA
OHMORI KENJI
KARASAWA AKIRA
OHMORI KENJI
Application Number:
PCT/JP2004/011571
Publication Date:
February 10, 2005
Filing Date:
August 05, 2004
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
IKEMURA TOSHIHIDE
KARASAWA AKIRA
OHMORI KENJI
IKEMURA TOSHIHIDE
KARASAWA AKIRA
OHMORI KENJI
International Classes:
A61P11/06; A61P11/08; A61P43/00; C07D337/06; (IPC1-7): A61K31/381; A61P11/06; A61P11/08; A61P43/00; C07D495/04
Domestic Patent References:
| WO1998046587A1 | 1998-10-22 | |||
| WO1997014672A1 | 1997-04-24 |
Foreign References:
| JPS6028972A | 1985-02-14 | |||
| JPS56150082A | 1981-11-20 | |||
| JPS6310784A | 1988-01-18 | |||
| JPH01308274A | 1989-12-12 |
Other References:
OHMORI K. ET AL.: "Ko-Alergy-yaku Ensan Olopatadine (ALLELOCK-Jo°)no Yakuri Sayo, Yakubutsu Dotai Oyobi Rinsho Seiseki", NICHIYAKURISHI, vol. 118, 2001, pages 51 - 58, XP002979108
OHMORI K. ET AL.: "Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug", JAPANESE JOURNAL OF PHARMACOLOGY, vol. 88, no. 4, 2002, pages 379 - 397, XP002995638
IKEMURA T. ET AL.: "KW-4679-induced inhibition of tachkininergic contraction in the guinea pig bronchi by prejunctional inhibition of peripheral sensory nerves", BRITISH JOURNAL OF PHARMACOLOGY, vol. 117, no. 5, 1996, pages 967 - 973, XP002995639
IKEMURA T. ET AL.: "Inhibitory effect of KW-4679, an anti-allergic drug, on tachykinin-mediated airway response induced by electric vagal stimulation in guinea pigs", JAPANESE JOURNAL OF PHARMACOLOGY, vol. 71, no. 2, 1996, pages 179 - 182, XP002995640
OHSHIMA E. ET AL.: "Synthesis and Antiallergic Activity of 11-(Aminoalkylidene)-6, 11-dihydrodibenz [b,e] oxepin Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, no. 11, 1992, pages 2074 - 2084, XP000615220
OHMORI K. ET AL.: "Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antiallergic drug", JAPANESE JOURNAL OF PHARMACOLOGY, vol. 88, no. 4, 2002, pages 379 - 397, XP002995638
IKEMURA T. ET AL.: "KW-4679-induced inhibition of tachkininergic contraction in the guinea pig bronchi by prejunctional inhibition of peripheral sensory nerves", BRITISH JOURNAL OF PHARMACOLOGY, vol. 117, no. 5, 1996, pages 967 - 973, XP002995639
IKEMURA T. ET AL.: "Inhibitory effect of KW-4679, an anti-allergic drug, on tachykinin-mediated airway response induced by electric vagal stimulation in guinea pigs", JAPANESE JOURNAL OF PHARMACOLOGY, vol. 71, no. 2, 1996, pages 179 - 182, XP002995640
OHSHIMA E. ET AL.: "Synthesis and Antiallergic Activity of 11-(Aminoalkylidene)-6, 11-dihydrodibenz [b,e] oxepin Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 35, no. 11, 1992, pages 2074 - 2084, XP000615220
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