Title:
PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ITCH
Document Type and Number:
WIPO Patent Application WO/2004/017995
Kind Code:
A1
Abstract:
Preventive and/or therapeutic drugs for itch containing as the active ingredient substances capable of suppressing the functions of GPR4 relating to signal transduction; and nitrogen-containing tricyclic compounds represented by the general formula (I), quaternary ammonium salts thereof, or pharmacologically acceptable salts of both: (I) wherein R1 is substituted or unsubstituted lower alkyl or the like; R2 is hydrogen, substituted or unsubstituted lower alkyl, or the like; R3 and R4 are each independently hydrogen, lower alkyl, or the like; n is 0 or 1; X is -(CH2)2- or the like; and Y is a group represented by the general formula (II): (II) (wherein W is CH or nitrogen; Z1 and Z2 are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like; and Z3 is hydrogen, substituted or unsubstituted lower alkyl, or the like).
Inventors:
SAKI MAYUMI (JP)
NONAKA HIROMI (JP)
MIYAJI HIROMASA (JP)
ICHIKAWA SHUNJI (JP)
TAKASHIMA CHIEMI (JP)
MATSUMURA TSUTOMU (JP)
ARAI HITOSHI (JP)
SASAKI KATSUTOSHI (JP)
KOBATAKE CHOEI (JP)
TSUKUMO YUKIHITO (JP)
IIDA KYOICHIRO (JP)
KUBOYAMA TAKESHI (JP)
MANABE HARUHIKO (JP)
NONAKA HIROMI (JP)
MIYAJI HIROMASA (JP)
ICHIKAWA SHUNJI (JP)
TAKASHIMA CHIEMI (JP)
MATSUMURA TSUTOMU (JP)
ARAI HITOSHI (JP)
SASAKI KATSUTOSHI (JP)
KOBATAKE CHOEI (JP)
TSUKUMO YUKIHITO (JP)
IIDA KYOICHIRO (JP)
KUBOYAMA TAKESHI (JP)
MANABE HARUHIKO (JP)
Application Number:
PCT/IB2003/003475
Publication Date:
March 04, 2004
Filing Date:
August 22, 2003
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
SAKI MAYUMI (JP)
NONAKA HIROMI (JP)
MIYAJI HIROMASA (JP)
ICHIKAWA SHUNJI (JP)
TAKASHIMA CHIEMI (JP)
MATSUMURA TSUTOMU (JP)
ARAI HITOSHI (JP)
SASAKI KATSUTOSHI (JP)
KOBATAKE CHOEI (JP)
TSUKUMO YUKIHITO (JP)
IIDA KYOICHIRO (JP)
KUBOYAMA TAKESHI (JP)
MANABE HARUHIKO (JP)
SAKI MAYUMI (JP)
NONAKA HIROMI (JP)
MIYAJI HIROMASA (JP)
ICHIKAWA SHUNJI (JP)
TAKASHIMA CHIEMI (JP)
MATSUMURA TSUTOMU (JP)
ARAI HITOSHI (JP)
SASAKI KATSUTOSHI (JP)
KOBATAKE CHOEI (JP)
TSUKUMO YUKIHITO (JP)
IIDA KYOICHIRO (JP)
KUBOYAMA TAKESHI (JP)
MANABE HARUHIKO (JP)
International Classes:
A61K31/519; A61K31/55; A61K31/7088; A61P17/04; A61P43/00; C07D401/14; C07D403/06; C07D417/14; C07D471/04; G01N33/50; A61K48/00; (IPC1-7): A61K45/00; A61K31/519; A61K31/55; A61K31/7088; A61K39/395; A61K48/00; A61P17/04; A61P43/00; C07D401/14; C07D403/06; C07D417/14; C07D471/14; C07D519/00
Domestic Patent References:
| WO2002024222A2 | 2002-03-28 | |||
| WO2002061087A2 | 2002-08-08 |
Foreign References:
| EP0549352A2 | 1993-06-30 | |||
| EP0325755A1 | 1989-08-02 | |||
| JPH0940662A | 1997-02-10 |
Other References:
"The Merck Manual of Diagnosis and Therapy Seventeenth Edition", 1999, MERCK RESEARCH LABORATORIES, article BEERS, M.H.: "Section 10 Dermatologic Disorders, Dermatitis", pages: 786 - 793, XP002974909
HEIBER,M ET AL.: "ISOLATION OF THREE NOVEL HUMAN ENCODING G PROTEIN-COUPLED RECEPTORS.", DNA CELL BIOL., vol. 14, no. 1, 1995, pages 25 - 35, XP002066093
MAHADEVANM M.S. ET AL: "ISOLATION OF A NOVEL G PROTEIN-COUPLED RECEPTOR (GPR4) LOCALIZED TO CHROMOSOME 19Q13.3.", GENOMICS, vol. 30, 1995, pages 84 - 88, XP002920408
HEIBER,M ET AL.: "ISOLATION OF THREE NOVEL HUMAN ENCODING G PROTEIN-COUPLED RECEPTORS.", DNA CELL BIOL., vol. 14, no. 1, 1995, pages 25 - 35, XP002066093
MAHADEVANM M.S. ET AL: "ISOLATION OF A NOVEL G PROTEIN-COUPLED RECEPTOR (GPR4) LOCALIZED TO CHROMOSOME 19Q13.3.", GENOMICS, vol. 30, 1995, pages 84 - 88, XP002920408
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