Title:
PRIMITIVE ENDODERM STEM CELL INDUCER
Document Type and Number:
WIPO Patent Application WO/2020/262531
Kind Code:
A1
Abstract:
The present invention pertains to: a primitive endoderm stem cell inducer containing a Wnt activator or a GSK3 inhibitor; a medium which is for inducing a primitive endoderm stem cell, contains said inducer, and does not contain serum; and a method which is for producing a primitive endoderm stem cell and comprises culturing a blastocyst in a serum-free medium containing a Wnt activator or a GSK3 inhibitor.
Inventors:
OHINATA YASUHIDE (JP)
KOSEKI HARUHIKO (JP)
KOSEKI HARUHIKO (JP)
Application Number:
PCT/JP2020/025018
Publication Date:
December 30, 2020
Filing Date:
June 25, 2020
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
C12N5/071
Domestic Patent References:
| WO2015125926A1 | 2015-08-27 | |||
| WO2019093340A1 | 2019-05-16 | |||
| WO2006128681A1 | 2006-12-07 |
Foreign References:
| JP2013066495A | 2013-04-18 |
Other References:
OHINATA, YASUHIDE: "Growing Primitive Endoderm Stem Cells", PROCEEDINGS OF BIOLOGICAL SCIENCES 2017, 15 November 2017 (2017-11-15), pages 1423
LI, ZHENDONG ET AL.: "Medaka cleavage embryos are capable of generating ES-like cell cultures", INT. J. BIOL. SCI., vol. 7, no. 4, 15 April 2011 (2011-04-15), pages 418 - 425, XP055030770
LI, ZHENDONG ET AL.: "Medaka cleavage embryos are capable of generating ES-like cell cultures", INT. J. BIOL. SCI., vol. 7, no. 4, 15 April 2011 (2011-04-15), pages 418 - 425, XP055030770
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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