Title:
PRIMORDIAL FOLLICLE ACTIVATOR AND APPLICATION THEREOF IN HUMAN OVARIAN CORTEX CULTURE
Document Type and Number:
WIPO Patent Application WO/2019/138268
Kind Code:
A1
Abstract:
Provided are a primordial follicle activator and an application thereof in the preparation of a human ovarian cortex culture; the primordial follicle activator is composed of a mammalian target of Rapamycin (mTOR) signal pathway activator and a phosphoinositide 3-kinase (PI3K) signal pathway activator; the mTOR signal pathway activator comprises mTOR signal pathway activator I, and the mTOR signal pathway activator I is 50-200 μM of phosphate; the PI3K signal pathway activator comprises PI3K signal pathway activator II, and the PI3K signal pathway activator II is 100-1000 μM of 740 Y-P.
Inventors:
WU TINGHE (CN)
LI JING (CN)
ZHANG JING (CN)
CHEN YONGSHENG (CN)
LI JING (CN)
ZHANG JING (CN)
CHEN YONGSHENG (CN)
Application Number:
PCT/IB2018/052447
Publication Date:
July 18, 2019
Filing Date:
April 09, 2018
Export Citation:
Assignee:
OVAHEALTH BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N5/075
Foreign References:
| CN104130972A | 2014-11-05 | |||
| CN102533642A | 2012-07-04 | |||
| CN103387960A | 2013-11-13 | |||
| US20170051249A1 | 2017-02-23 |
Other References:
SUN, XINHUI ET AL.: "New Strategy for in Vitro Activation of Primordial Follicles with mTOR and PI3K Stimulators", CELL CYCLE, vol. 14, no. 5, 1 March 2015 (2015-03-01), pages 721 - 731, XP055624943
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD (CN)
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