Title:
PRMT5 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/037608
Kind Code:
A1
Abstract:
Provided is a PRMT5 inhibitor represented by formula (I), or a pharmaceutically acceptable salt, an isotopic variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate or a solvate thereof. Also provided is a method for preparing the compound, a pharmaceutical composition comprising the compound, and use of the compound in preventing and treating a cancer.
Inventors:
YANG XU (CN)
MENG QINGHUA (CN)
LIU LEI (CN)
WANG HUTING (CN)
SHI LEI (CN)
DU HAOLIN (CN)
GAO BEIRONG (CN)
WANG JIANHAO (CN)
KONG DESHENG (CN)
MENG QINGHUA (CN)
LIU LEI (CN)
WANG HUTING (CN)
SHI LEI (CN)
DU HAOLIN (CN)
GAO BEIRONG (CN)
WANG JIANHAO (CN)
KONG DESHENG (CN)
Application Number:
PCT/CN2023/113653
Publication Date:
February 22, 2024
Filing Date:
August 18, 2023
Export Citation:
Assignee:
BEIJING EARTHWISE TECH CO LTD (CN)
International Classes:
C07D401/12; A61K31/4995; A61K31/5377; A61P35/00; C07D405/14; C07D417/14; C07D471/04
Domestic Patent References:
| WO2014100716A1 | 2014-06-26 | |||
| WO2022026892A1 | 2022-02-03 | |||
| WO2023146991A1 | 2023-08-03 |
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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