Title:
PRMT5 INHIBITORS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/002376
Kind Code:
A1
Abstract:
The present invention provides a class of compounds with inhibitory activity against methyltransferases. Particularly, the present invention provides a class of compounds with inhibitory activity against PRMT5. The compounds can be used for preparing pharmaceutical compositions for treating PRMT5 activity-related diseases. Formula (I) and formula (II).
Inventors:
WANG LONG (CN)
WU HAIPING (CN)
MI YUAN (CN)
LIU YILIN (CN)
FU XINGNIAN (CN)
WANG MENG (CN)
SHI HUI (CN)
GUO JIANNAN (CN)
WU HAIPING (CN)
MI YUAN (CN)
LIU YILIN (CN)
FU XINGNIAN (CN)
WANG MENG (CN)
SHI HUI (CN)
GUO JIANNAN (CN)
Application Number:
PCT/CN2023/105593
Publication Date:
January 04, 2024
Filing Date:
July 03, 2023
Export Citation:
Assignee:
CYTOSINLAB THERAPEUTICS CO LTD (CN)
International Classes:
C07F5/02; A61K31/4353; A61P35/00; C07D487/14; C07D491/04; C07D491/14
Domestic Patent References:
| WO2022132914A1 | 2022-06-23 | |||
| WO2020033282A1 | 2020-02-13 | |||
| WO2021163344A1 | 2021-08-19 | |||
| WO2020033285A1 | 2020-02-13 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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