Title:
PRO-INFLAMMATORY AND ADJUVANT FUNCTIONS OF TOLL-LIKE RECEPTOR 4 ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2016/115097
Kind Code:
A3
Abstract:
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Inventors:
KAGAN JONATHAN C (US)
Application Number:
PCT/US2016/012994
Publication Date:
September 09, 2016
Filing Date:
January 12, 2016
Export Citation:
Assignee:
CHILDREN'S MEDICAL CENTER CORP (US)
International Classes:
A61K39/39; A61P39/00
Domestic Patent References:
| WO2013088245A1 | 2013-06-20 | |||
| WO2004006910A1 | 2004-01-22 |
Foreign References:
| US20100151000A1 | 2010-06-17 | |||
| US20080311152A1 | 2008-12-18 |
Other References:
KIM, JUYONG BRIAN ET AL.: "Paraoxonase-2 Modulates Stress Response of Endothelial Cells to Oxidized Phospholipids and a Bacterial Quorum-Sensing Molecule", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 31, 2011, pages 2624 - 2633, XP055467390
Attorney, Agent or Firm:
CORLESS, Peter, F. et al. (P.C.One Financial Cente, Boston MA, US)
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