Title:
PROBE AND METHOD FOR DETECTING TRANSCRIPT RESULTING FROM FUSION GENE AND/OR EXON SKIPPING
Document Type and Number:
WIPO Patent Application WO/2019/004080
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method or the like with which it is possible to easily detect a transcript resulting from a fusion gene and/or exon skipping. According to one embodiment, the present invention pertains to: a probe set for determining the existence or expression level of a transcript of a fusion gene on the genome; a probe set for determining the existence or expression level of a transcript resulting from exon skipping; a kit comprising said probe sets; a method for determining, by using said probe sets, the existence or expression level of a transcript of a fusion gene on the genome; or a method or the like for determining the existence or expression level of a transcript resulting from exon skipping.
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Inventors:
MANO HIROYUKI (JP)
KOHSAKA SHINJI (JP)
UENO TOSHIHIDE (JP)
KOHSAKA SHINJI (JP)
UENO TOSHIHIDE (JP)
Application Number:
PCT/JP2018/023799
Publication Date:
January 03, 2019
Filing Date:
June 22, 2018
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C12N15/11; C12Q1/6809; C12Q1/6876
Domestic Patent References:
| WO2017015513A1 | 2017-01-26 |
Foreign References:
| JP2016510992A | 2016-04-14 | |||
| JP2016515384A | 2016-05-30 | |||
| JP2015516814A | 2015-06-18 | |||
| JP2017125074A | 2017-07-20 |
Other References:
KORAZOWA: "Overview of Target Enrichment Strategies", CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, vol. 112, no. 1, pages 7.21.1 - 7.21.23, XP055581262, DOI: 10.1002/0471142727.mb0721s112
DUNCAVAGE, E.J. ET AL.: "Targeted next generation sequencing of clinically significant gene mutations and translocations in leukemia", MODERN PATHOLOGY, vol. 25, no. 6, 16 March 2012 (2012-03-16), pages 795 - 804, XP055235397, DOI: 10.1038/modpathol.2012.29
J. ERIKSON ET AL., PROC. NATL. ACAD. SCI., vol. 83, 1986, pages 1807 - 1811
M. SODA ET AL., NATURE, vol. 448, 2007, pages 561 - 566
K. TAKEUCHI ET AL., NAT. MED., vol. 18, 2012, pages 382 - 384
L. FERNANDEZ-CUESTA ET AL., CANCER DISCOV., vol. 4, 2014, pages 415 - 422
A. VAISHNAVI ET AL., NAT. MED., vol. 19, 2013, pages 1469 - 1472
R. WANG, L ET AL., CLIN. CANCER RES., vol. 20, 2014, pages 4107 - 4114
RICK KAMPS ET AL., INT. J. MOL. SCI., vol. 18, no. 2, 2017, pages 308
INT. NEUROUROL. J., vol. 20, no. 2, 2016, pages 76 - 83
ALTSCHUL ET AL., NUC. ACIDS. RES., vol. 25, 1977, pages 3389 - 3402
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
GREENSAMBROOK: "Molecular Cloning", 2012, COLD SPRING HARBOR LABORATORY PRESS
RYAN TEWHEY ET AL., GENOME BIOLOGY, vol. 10, 2009, pages R116
See also references of EP 3647420A4
DUNCAVAGE, E.J. ET AL.: "Targeted next generation sequencing of clinically significant gene mutations and translocations in leukemia", MODERN PATHOLOGY, vol. 25, no. 6, 16 March 2012 (2012-03-16), pages 795 - 804, XP055235397, DOI: 10.1038/modpathol.2012.29
J. ERIKSON ET AL., PROC. NATL. ACAD. SCI., vol. 83, 1986, pages 1807 - 1811
M. SODA ET AL., NATURE, vol. 448, 2007, pages 561 - 566
K. TAKEUCHI ET AL., NAT. MED., vol. 18, 2012, pages 382 - 384
L. FERNANDEZ-CUESTA ET AL., CANCER DISCOV., vol. 4, 2014, pages 415 - 422
A. VAISHNAVI ET AL., NAT. MED., vol. 19, 2013, pages 1469 - 1472
R. WANG, L ET AL., CLIN. CANCER RES., vol. 20, 2014, pages 4107 - 4114
RICK KAMPS ET AL., INT. J. MOL. SCI., vol. 18, no. 2, 2017, pages 308
INT. NEUROUROL. J., vol. 20, no. 2, 2016, pages 76 - 83
ALTSCHUL ET AL., NUC. ACIDS. RES., vol. 25, 1977, pages 3389 - 3402
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
GREENSAMBROOK: "Molecular Cloning", 2012, COLD SPRING HARBOR LABORATORY PRESS
RYAN TEWHEY ET AL., GENOME BIOLOGY, vol. 10, 2009, pages R116
See also references of EP 3647420A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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