Title:
PROBE FOR UNIVERSAL DETECTION OF CIRCULATING TUMOR CELLS
Document Type and Number:
WIPO Patent Application WO/2019/161139
Kind Code:
A3
Abstract:
Disclosed are probes based on papilloma virus and modified SV40 that can be used for detecting circulating tumor cells (CTCs) in the blood stream, methods for manufacturing such probes, and methods for using such probes.
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Inventors:
ZHANG SHAUN (US)
FU XINPING (US)
FU XINPING (US)
Application Number:
PCT/US2019/018120
Publication Date:
November 07, 2019
Filing Date:
February 14, 2019
Export Citation:
Assignee:
UNIV HOUSTON SYSTEM (US)
International Classes:
A61K48/00; C12N7/00; C12N15/86; C12N15/867; C12N15/87; C12Q1/02
Foreign References:
| US20170335292A1 | 2017-11-23 | |||
| US20170121688A1 | 2017-05-04 |
Other References:
LIU ET AL.: "Efficiency of delivery of DNA to cells by bovine papillomavirus type-1 L1/L2 pseudovirions", APPL MICROBIOL BIOTECHNOL, vol. 56, no. 1-2, 1 July 2001 (2001-07-01), pages 150 - 156, XP055650639, DOI: 10.1007/s002530100655
KINES ET AL.: "Human papillomavirus capsids preferentially bind and infect tumor cells", INT J CANCER, vol. 138, no. 4, 2016, pages 901 - 911, XP055353389, DOI: 10.1002/ijc.29823
NANDI ET AL.: "Characterization of a surrogate TATA box promoter that regulates in vitro transcription of the simian virus 40 major late gene", MOL CELL BIOL., vol. 5, no. 3, March 1985 (1985-03-01), pages 591 - 594, XP055650641, DOI: 10.1128/MCB.5.3.591
BUCK ET AL.: "Arrangement of L2 within the papillomavirus capsid", J VIROL ., vol. 82, no. 11, June 2008 (2008-06-01), pages 5190 - 5197, XP055650649, Retrieved from the Internet DOI: 10.1128/JVI.02726-07
HOJEIJ ET AL.: "Immunogenic Human Papillomavirus Pseudovirus-Mediated Suicide- Gene Therapy for Bladder Cancer", INT J MOL SCI., vol. 17, no. 7, 2016, pages 1125, XP055353389
ZHANG ET AL.: "The prognostic and diagnostic value of circulating tumor cells in bladder cancer and upper tract urothelial carcinoma: a meta-analysis of 30 published studies", ONCOTARGET, vol. 8, no. 35, 29 August 2017 (2017-08-29), pages 59527 - 59538, XP55650661, DOI: 10.18632/oncotarget.18521
KINES ET AL.: "Human papillomavirus capsids preferentially bind and infect tumor cells", INT J CANCER, vol. 138, no. 4, 2016, pages 901 - 911, XP055353389, DOI: 10.1002/ijc.29823
NANDI ET AL.: "Characterization of a surrogate TATA box promoter that regulates in vitro transcription of the simian virus 40 major late gene", MOL CELL BIOL., vol. 5, no. 3, March 1985 (1985-03-01), pages 591 - 594, XP055650641, DOI: 10.1128/MCB.5.3.591
BUCK ET AL.: "Arrangement of L2 within the papillomavirus capsid", J VIROL ., vol. 82, no. 11, June 2008 (2008-06-01), pages 5190 - 5197, XP055650649, Retrieved from the Internet
HOJEIJ ET AL.: "Immunogenic Human Papillomavirus Pseudovirus-Mediated Suicide- Gene Therapy for Bladder Cancer", INT J MOL SCI., vol. 17, no. 7, 2016, pages 1125, XP055353389
ZHANG ET AL.: "The prognostic and diagnostic value of circulating tumor cells in bladder cancer and upper tract urothelial carcinoma: a meta-analysis of 30 published studies", ONCOTARGET, vol. 8, no. 35, 29 August 2017 (2017-08-29), pages 59527 - 59538, XP55650661, DOI: 10.18632/oncotarget.18521
Attorney, Agent or Firm:
LLAGOSTERA, Domingo, M. (US)
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