Title:
PROBIOTIC MINERAL MATERIAL COMPOSITE PREPARATION AND APPLICATION OF MINERAL MATERIALS IN PREPARATION OF DRUGS FOR INHIBITING MALIGNANT TUMOR GROWTH
Document Type and Number:
WIPO Patent Application WO/2021/138979
Kind Code:
A1
Abstract:
Disclosed in the present invention is a probiotic mineral material composite preparation. Probiotic microspheres are obtained by mixing a probiotic culture solution subjected to anaerobic culture with a mineral material suspension and then continuing to culture; the probiotics are lactobacillus, bifidobacterium, enterococcus faecalis or bacillus subtilis; and mineral materials are montmorillonite, diatomite, kaolin, attapulgite or clay particles. Moreover, disclosed are the probiotic mineral material composite preparation, an application of the mineral materials in preparation of drugs for inhibiting malignant tumor growth, and corresponding drugs for inhibiting malignant tumor growth. Mouse experiments show that the probiotic mineral material composite preparation and the mineral materials have an obvious inhibiting effect on malignant tumors.
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Inventors:
DONG LEI (CN)
HAN CONGWEI (CN)
HAN CONGWEI (CN)
Application Number:
PCT/CN2020/076550
Publication Date:
July 15, 2021
Filing Date:
February 25, 2020
Export Citation:
Assignee:
NANJING UNIVERSITY OF TECHNOLOGY (CN)
International Classes:
A61K35/747; A61K9/50; A61K35/741; A61K35/742; A61K35/745; A61K47/46; A61K33/00; A61K33/06; A61K33/12; A61P35/00
Foreign References:
| CN111012794A | 2020-04-17 | |||
| CN108135240A | 2018-06-08 | |||
| CN104364220A | 2015-02-18 | |||
| CN109157541A | 2019-01-08 | |||
| CN105169375A | 2015-12-23 | |||
| CN109172602A | 2019-01-11 | |||
| CN104719887A | 2015-06-24 | |||
| CN104593352A | 2015-05-06 | |||
| CN110354227A | 2019-10-22 |
Other References:
MA WENTING: "The Processes and Mechanisms of Bacteria Biofilm Formation in the Precence of Soil Minerals", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 1 June 2017 (2017-06-01), pages 1 - 112, XP055827889
XUE JIN: "The Research and Evaluation of Modified Clay as Drug and Gene Co-delivery System for Gastric Therapy", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 20 January 2013 (2013-01-20), pages 1 - 96, XP055827897
WANG YOUZHI , LIU GUIYING: "Medical stone and tumor prevention and treatment", INFORMATION ON TRADITIONAL CHINESE MEDICINE, 10 May 1999 (1999-05-10), XP055827902, ISSN: 1002-2406, DOI: 10.19656/j.cnki.1002-2406.1999.03.001
ZHU YA-PIAG;GUO HENG-ZHAO: "Advances in intestinal microecology and gastrointestinal cancer", ELECTRONIC JOURNAL OF METABOLISM AND NUTRITION OF CANCER, vol. 6, no. 4, 9 December 2019 (2019-12-09), pages 488 - 493, XP055827916, DOI: 10.16689/j.cnki.cn11-9349/r.2019.04.019
BEKAROĞLU MAIDE GÖKÇE, NURILI FUAD, İŞÇI SEVIM: "Montmorillonite as Imaging and Drug Delivery Agent for Cancer Therapy", APPLIED CLAY SCIENCE, vol. 162, 15 September 2018 (2018-09-15), pages 469 - 477, XP055827925, ISSN: 0169-1317, DOI: 10.1016/j.clay.2018.06.039
XUE JIN: "The Research and Evaluation of Modified Clay as Drug and Gene Co-delivery System for Gastric Therapy", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 20 January 2013 (2013-01-20), pages 1 - 96, XP055827897
WANG YOUZHI , LIU GUIYING: "Medical stone and tumor prevention and treatment", INFORMATION ON TRADITIONAL CHINESE MEDICINE, 10 May 1999 (1999-05-10), XP055827902, ISSN: 1002-2406, DOI: 10.19656/j.cnki.1002-2406.1999.03.001
ZHU YA-PIAG;GUO HENG-ZHAO: "Advances in intestinal microecology and gastrointestinal cancer", ELECTRONIC JOURNAL OF METABOLISM AND NUTRITION OF CANCER, vol. 6, no. 4, 9 December 2019 (2019-12-09), pages 488 - 493, XP055827916, DOI: 10.16689/j.cnki.cn11-9349/r.2019.04.019
BEKAROĞLU MAIDE GÖKÇE, NURILI FUAD, İŞÇI SEVIM: "Montmorillonite as Imaging and Drug Delivery Agent for Cancer Therapy", APPLIED CLAY SCIENCE, vol. 162, 15 September 2018 (2018-09-15), pages 469 - 477, XP055827925, ISSN: 0169-1317, DOI: 10.1016/j.clay.2018.06.039
Attorney, Agent or Firm:
JIANGSU PHAEDO LAW FIRM (CN)
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