Title:
PROCEDURE FOR THE PREPARATION OF ABIRATERONE ACETATE AND INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/114518
Kind Code:
A3
Abstract:
Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a crystalline intermediate that makes the process particularly suitable for implementation on an industrial scale. There is also provided a process for the production of abiraterone acetate by acetylation of abiraterone in the absence of bases or acetylation catalysts.
Inventors:
CRISTIANO TANIA (IT)
ALPEGIANI MARCO (IT)
ALPEGIANI MARCO (IT)
Application Number:
PCT/IB2015/050613
Publication Date:
December 17, 2015
Filing Date:
January 27, 2015
Export Citation:
Assignee:
OLON SPA (IT)
International Classes:
C07J31/00; C07J43/00; C07J1/00
Domestic Patent References:
| WO1993020097A1 | 1993-10-14 | |||
| WO2006021777A1 | 2006-03-02 | |||
| WO2013053691A1 | 2013-04-18 |
Other References:
ARCADI A ET AL: "Palladium-catalysed coupling of aryl and viny triflates or halides with 2-ethynylaniline: An efficient route to functionalized 2-substituted indoles", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 30, no. 19, 1 January 1989 (1989-01-01), pages 2581 - 2584, XP002258672, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(01)80456-1
Attorney, Agent or Firm:
MINOJA, Fabrizio (Via Plinio 63, Milano, IT)
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