Title:
PROCESS FOR THE ACTIVATION OF THE C-H BOND OF ORGANIC COMPOUNDS AND A REACTIONS SYSTEM SERVING THE PROCESS
Document Type and Number:
WIPO Patent Application WO/2014/006433
Kind Code:
A3
Abstract:
A process is disclosed for the activation of the single covalent carbon-hydrogen bond of organic substrate compounds, and for the reaction, in particular deuteratrion thereof within mild reaction conditions, wherein said organic substrate compound is contacted with a Rutenium-complex, a phosphine, and a source of a hydrogen-substituent, thus the hydrogen of the C-H-bond is substituted by a hydrogen-substituent through the activation of the C-H bond by an in situ prepared Ru-phosphine catalyst. A reaction system for reacting of the C-H-bond is also disclosed. The process makes possible the selective reaction of the C-H-bond.
Inventors:
GYORVARINE HORVATH HENRIETTA (HU)
PAPP GABOR (HU)
LAURENCZY GABOR (CH)
JOO FERENC (HU)
PAPP GABOR (HU)
LAURENCZY GABOR (CH)
JOO FERENC (HU)
Application Number:
PCT/HU2013/000064
Publication Date:
February 27, 2014
Filing Date:
July 05, 2013
Export Citation:
Assignee:
DEBRECENI EGYETEM (HU)
International Classes:
C07B59/00; C07F15/00
Other References:
GÜLLIN ERDOGAN ET AL.: "Mild and selective deuteration and isomerization of alkenes by a bifunctional catalyst and deuterium oxide", J. AM. CHEM. SOC., vol. 131, 2009, pages 10354 - 10355, XP002716924
MARTIN H.G. PRECHTL ET AL.: "H/D exchange at aromatic and heteroaromnatic hydrocarbons using D2O as the deuterium source and ruthenium dihydrogen complexes as the catalyst", ANGEW. CHEM. INT. ED., vol. 46, 2007, pages 2269 - 2272, XP002716925
TAKAHASHI M ET AL: "Ruthenium catalyzed deuterium labelling of alpha-carbon in primary alcohol and primary/secondary amine in D2O", CHEMISTRY LETTERS, CHEMICAL SOCIETY OF JAPAN, JAPAN, vol. 34, no. 2, 15 January 2005 (2005-01-15), pages 192 - 193, XP009153705, ISSN: 0366-7022
MARTIN H.G. PRECHTL ET AL.: "H/D exchange at aromatic and heteroaromnatic hydrocarbons using D2O as the deuterium source and ruthenium dihydrogen complexes as the catalyst", ANGEW. CHEM. INT. ED., vol. 46, 2007, pages 2269 - 2272, XP002716925
TAKAHASHI M ET AL: "Ruthenium catalyzed deuterium labelling of alpha-carbon in primary alcohol and primary/secondary amine in D2O", CHEMISTRY LETTERS, CHEMICAL SOCIETY OF JAPAN, JAPAN, vol. 34, no. 2, 15 January 2005 (2005-01-15), pages 192 - 193, XP009153705, ISSN: 0366-7022
Attorney, Agent or Firm:
DANUBIA PATENT & LAW OFFICE LLC (Budapest, HU)
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