Title:
PROCESS FOR COATING N-[N-(3,3-DIMETHYLBUTYL)-L-$g(a)-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER ONTO A CARRIER
Document Type and Number:
WIPO Patent Application WO/2001/010241
Kind Code:
A2
Abstract:
The present invention relates to a process for coating N-[N-(3,3-dimethylbutyl)-L-$g(a)-aspartyl]-L-phenylalanine 1-methyl ester onto a carrier. The invention also relates to N-[N-(3,3-dimethylbutyl)-L-$g(a)-aspartyl]-L-phenylalanine 1-methyl ester coated carrier compositions.
Inventors:
TOWB ALLAN
NOLTE DOUGLAS
NOLTE DOUGLAS
Application Number:
PCT/US2000/040565
Publication Date:
February 15, 2001
Filing Date:
August 04, 2000
Export Citation:
Assignee:
NUTRASWEET CO (US)
International Classes:
A23L27/00; A23L27/30; (IPC1-7): A23L1/00
Domestic Patent References:
| WO1999062354A1 | 1999-12-09 | |||
| WO2000015050A1 | 2000-03-23 |
Foreign References:
| US5480668A | 1996-01-02 | |||
| EP0303295A2 | 1989-02-15 |
Other References:
BUVARDI: "The Merck Index 12th edition" 1996 , MERCK & CO. , WHITEHOUSE STATION, NJ, US XP002156948 022080 8873. Sorbitol 4467. Glucose
PATENT ABSTRACTS OF JAPAN vol. 8, no. 162 (C-235), 26 July 1984 (1984-07-26) & JP 59 063158 A (AJINOMOTO KK)
PATENT ABSTRACTS OF JAPAN vol. 8, no. 162 (C-235), 26 July 1984 (1984-07-26) & JP 59 063158 A (AJINOMOTO KK)
Attorney, Agent or Firm:
Mandra, Raymond R. (Cella Harper & Scinto 30 Rockefeller Plaza
New York, NY, US)
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Claims:
What is claimed is:
| 1. | A method of coating N [N (3,3dimethylbutyl)La aspartyl]Lphenylalanine 1methyl ester onto a carrier comprising the steps of: (a) heating the carrier to a temperature above the melting point of the N [N (3,3dimethylbutyl)La aspartyl]Lphenylalanine 1methyl ester; (b) combining the N [N (3,3dimethylbutyl)La aspartyl]Lphenylalanine 1methyl ester with the heated carrier to form a mixture; and (c) cooling the mixture of carrier and N [N (3,3 dimethylbutyl)Laaspartyl]Lphenylalanine 1methyl ester to form a N [N (3,3dimethylbutyl)Laaspartyl] Lphenylalanine 1methyl ester coated carrier composition. |
| 2. | The method according to claim 1, wherein the carrier is selected from the group consisting of sucrose, citric acid, maltodextrin, dextrose, lactose, inulin, erythritol, sorbitol, maltitol, lactitol, isomalt, maltose, tagatose, fructose, polyols, polydextrose, cellulose and cellulose derivatives, aspartame, acesulfame salts, sucralose, cyclamate, saccharin, stevioside, alitame, malic acid and mixtures thereof. |
| 3. | The method according to claim 2, wherein the carrier is selected from the group consisting of sucrose, citric acid, lactose, acesulfameK and mixtures thereof. |
| 4. | The method according to claim 1, wherein the carrier is heated to a temperature from about 80°C to about 150°C. |
| 5. | The method according to claim 4, wherein the carrier is heated to a temperature from about 105°C to about 120°C. |
| 6. | The method according to claim 1, wherein the N [N (3,3dimethylbutyl)Laaspartyl]Lphenylalanine 1 methyl ester is combined with the carrier in an amount from about 0.01% to about 12% by weight of the carrier. |
| 7. | The method according to claim 6, wherein the N [N (3,3dimethylbutyl)Laaspartyl]Lphenylalanine 1 methyl ester is combined with the carrier in an amount from about 0.1% to about 5% by weight of the carrier. |
| 8. | The method according to claim 7, wherein the N [N (3,3dimethylbutyl)Laaspartyl]Lphenylalanine 1 methyl ester is combined with the carrier in an amount from about 1% to about 2.5% by weight of the carrier. |
| 9. | A N [N (3,3dimethylbutyl)Laaspartyl]L phenylalanine 1methyl ester coated carrier composition comprising a carrier and N [N (3,3dimethylbutyl)La aspartyl]Lphenylalanine 1methyl ester made according to the method comprising the steps of: (a) heating the carrier to a temperature above the melting point of the N [N (3,3dimethylbutyl)La aspartyl]Lphenylalanine 1methyl ester; (b) combining the N [N (3,3dimethylbutyl)La aspartyl]Lphenylalanine 1methyl ester with the heated carrier to form a mixture; and (c) cooling the mixture of carrier and N [N (3,3 dimethylbutyl)Laaspartyl]Lphenylalanine 1methyl ester to form a N [N (3, 3dimethylbutyl)Laaspartyl] Lphenylalanine 1methyl ester coated carrier composition. |
| 10. | The N [N (3, 3dimethylbutyl)Laaspartyl]L phenylalanine 1methyl ester coated carrier composition according to claim 9, wherein the carrier is selected from the group consisting of sucrose, citric acid, maltodextrin, dextrose, lactose, inulin, erythritol, sorbitol, maltitol, lactitol, isomalt, maltose, tagatose, fructose, polyols, polydextrose, cellulose and cellulose derivatives, aspartame, acesulfame salts, sucralose, cyclamate, saccharin, stevioside, alitame, malic acid and mixtures thereof. |
| 11. | The N [N (3, 3dimethylbutyl)Laaspartyl]L phenylalanine 1methyl ester coated carrier composition according to claim 10, wherein the carrier is selected from the group consisting of sucrose, citric acid, lactose, acesulfameK and mixtures thereof. |
| 12. | The N [N (3,3dimethylbutyl)Laaspartyl]L phenylalanine 1methyl ester coated carrier composition according to claim 9, wherein the carrier is heated to a temperature from about 80°C to about 150°C. |
| 13. | The N [N (3,3dimethylbutyl)Laaspartyl]L phenylalanine 1methyl ester coated carrier composition according to claim 12, wherein the carrier is heated to a temperature from about 105°C to about 120°C. |
| 14. | The N [N (3,3dimethylbutyl)Laaspartyl]L phenylalanine 1methyl ester coated carrier composition according to claim 9, wherein the N [N (3,3 dimethylbutyl)Laaspartyl]Lphenylalanine 1methyl ester is combined with the carrier in an amount from about 0.01% to about 12% by weight of the carrier. |
| 15. | The N [N (3,3dimethylbutyl)Laaspartyl]L phenylalanine 1methyl ester coated carrier composition according to claim 14, wherein the N [N (3,3 dimethylbutyl)Laaspartyl]Lphenylalanine 1methyl ester is combined with the carrier in an amount from about 0.1% to about 5% by weight of the carrier. |
| 16. | The N [N (3,3dimethylbutyl)Laaspartyl]L phenylalanine 1methyl ester coated carrier composition according to claim 14, wherein the N [N (3,3 dimethylbutyl)Laaspartyl]Lphenylalanine 1methyl ester is combined with the carrier in an amount from about 1% to about 2.5% by weight of the carrier. |
| 17. | A method of sweetening a food by including in said food a N [N (3, 3dimethylbutyl)Laaspartyl]L phenylalanine 1methyl ester coated carrier composition according to claim 9 in an amount effective to sweeten said food. |
| 18. | The method according to claim 17, wherein said food is selected from the group consisting of beverages, fluid dairy products, condiments, baked goods, frostings, bakery fillings, candy and chewing gum. |
| 19. | A method of sweetening a tabletop sweetener by including in said tabletop sweetener a N [N (3,3 dimethylbutyl)Laaspartyl]Lphenylalanine 1methyl ester coated carrier composition according to claim 9 in an amount effective to sweeten said tabletop sweetener. |
| 20. | A sweetened food comprising a N [N (3,3 dimethylbutyl)Laaspartyl]Lphenylalanine 1methyl ester coated carrier composition according to claim 9 in an amount effective to sweeten the food. |
| 21. | The sweetened food according to claim 20, wherein said food is selected from the group consisting of beverages, fluid dairy products, condiments, baked goods, frostings, bakery fillings, candy and chewing gum. |
| 22. | A tabletop sweetener comprising a N [N (3,3 dimethylbutyl)Laaspartyl]Lphenylalanine 1methyl ester coated carrier composition according to claim 9 in an amount effective to sweeten said tabletop sweetener. |
Description:
INTERNATIONAL SEARCH REPORT Inten nal Application No PCT/US 00/40565 C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category ° Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No. A PATENT ABSTRACTS OF JAPAN 1 vol. 8, no. 162 (C-235), 26 July 1984 (1984-07-26) &JP 59 063158 A (AJINOMOTO KK) abstract A US 5 480 668 A (NOFRE ET AL.) 1-22 2 January 1996 (1996-01-02) column 5-column 6; claims 1,3,6 A EP 0 303 295 A (MITSUBISHI CASEI CORP.) 1-22 15 February 1989 (1989-02-15) claims; examples INTERNATIONAL SEARCH REPORT Interr rial Application No ..., ormation on patent family members PCT/US 00/40565 Patent document Publication Patent cited in search report date member (s) date WO 9962354 A 09-12-1999 AU 7822398 A 20-12-1999 WO 0015050 A 23-03-2000 AU 6150599 A 03-04-2000 JP 59063158 A 10-04-1984 JP 1913638 C 09-03-1995 JP 4012104 B 03-03-1992 US 5480668 A 02-01-1996 FR 2697844 A 13-05-1994 AT 138935 T 15-06-1996 AU 664663 B 23-11-1995 AU 5468194 A 08-06-1994 BG 61609 B 30-01-1998 BG 99299 A 29-09-1995 CA 2139233 A 26-05-1994 CN 1090571 A, B 10-08-1994 CZ 9403319 A 18-10-1995 DE 69303032 D 11-07-1996 DE 69303032 T 02-10-1996 DK 669935 T 01-07-1996 EP 0669935 A 06-09-1995 ES 2091114 T 16-10-1996 FI 945451 A 22-12-1994 WO 9411391 A 26-05-1994 GR 3020164 T 30-09-1996 HU 72192 A, B 28-03-1996 IL 107551 A 16-08-1998 JP 2818032 B 30-10-1998 JP 8503206 T 09-04-1996 KR 254297 B 01-05-2000 LT 1457 A, B 15-06-1994 MD 960256 A 31-03-1998 NO 945090 A 30-12-1994 NZ 257870 A 26-03-1996 PL 306841 A 18-04-1995 RO 112621 B 28-11-1997 RU 2107071 C 20-03-1998 SK 158694 A 10-05-1995 ZA 9308430 A 13-06-1994 EP 303295 A 15-02-1989 JP 1047348 A 21-02-1989 JP 2005043 C 11-01-1996 JP 7028669 B 05-04-1995 DE 3873445 A 10-09-1992 DE 3873445 T 04-03-1993 US 4883685 A 28-11-1989