Title:
PROCESS FOR CRYSTALLIZATION OF RAMIPRIL AND PREPARATION OF A HYDRATED FORM THEREOF
Document Type and Number:
WIPO Patent Application WO2005068422
Kind Code:
A3
Abstract:
The present invention relates to a novel method for obtaining (2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-amino] propanoyl] octahydro cyclopenta[b] pyrrole-2-carboxylic acid, viz. Ramipril(I) in high optical purity, free of other stereoisomers, and in high bulk density. The present invention also relates to a novel hydrated form of Ramipril(I) and a process for preparation thereof.
Inventors:
SINGH GIRIJ PAL (IN)
RANANAWARE UMESH BABANRAO (IN)
DHAKE VILAS NATHU (IN)
RANANAWARE UMESH BABANRAO (IN)
DHAKE VILAS NATHU (IN)
Application Number:
PCT/IN2005/000019
Publication Date:
January 19, 2006
Filing Date:
January 17, 2005
Export Citation:
Assignee:
LUPIN LTD (IN)
SINGH GIRIJ PAL (IN)
RANANAWARE UMESH BABANRAO (IN)
DHAKE VILAS NATHU (IN)
SINGH GIRIJ PAL (IN)
RANANAWARE UMESH BABANRAO (IN)
DHAKE VILAS NATHU (IN)
International Classes:
C07D209/52; (IPC1-7): C07D209/52
Domestic Patent References:
| WO2004064809A1 | 2004-08-05 |
Foreign References:
| US6407262B1 | 2002-06-18 | |||
| US4587258A | 1986-05-06 | |||
| US6541635B1 | 2003-04-01 | |||
| US5061722A | 1991-10-29 |
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