PROCESS FOR THE CYANATION OF ALDEHYDES - KING S COLLEGE LONDON AN INSTI

Title:

PROCESS FOR THE CYANATION OF ALDEHYDES

Document Type and Number:

WIPO Patent Application WO2002010095

Kind Code:

A3

Abstract:

A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si-CN bond or a C-(C=O)-CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.

Inventors:

NORTH MICHAEL (GB)
BELOKON YURI (RU)

Application Number:

PCT/GB2001/003456

Publication Date:

April 18, 2002

Filing Date:

August 01, 2001

Export Citation:

Click for automatic bibliography generation Help

Assignee:

KING S COLLEGE LONDON AN INSTI (GB)
NESMEYANOV INST OF ORGANOELEME (RU)
NORTH MICHAEL (GB)
BELOKON YURI (RU)

International Classes:

B01J31/18; B01J31/22; C07B53/00; C07B61/00; C07C253/00; C07C255/38; C07C255/14; C07C255/15; (IPC1-7): C07C253/00

Foreign References:

EP0561637A2	1993-09-22
US4336206A	1982-06-22

Other References:

PATENT ABSTRACTS OF JAPAN vol. 1995, no. 06 31 July 1995 (1995-07-31)
PATENT ABSTRACTS OF JAPAN vol. 018, no. 680 (C - 1291) 21 December 1994 (1994-12-21)
Y.N. BELOKON E.A.: "The asymmetric Addition of trimethylsilyl cyanide to aldehydes catalyzed by chiral (salen)titanium complexes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 121, 1999, DC US, pages 3968 - 3973, XP002187021

Download PDF:

View/Download PDF PDF Help

Previous Patent: METHOD FOR SELECTIVE CHLORINATION IN MICROREACTORS

Next Patent: A PROCESS FOR SEPARATING O- AND P-SUBSTITUTED BENZENE COMPOUNDS