PROCESS FOR ENANTIOSEPARATION OF CHIRAL SYSTEMS WITH COMPOUND FORMATION USING TWO SUBSEQUENT CRYSTALLIZATION STEPS

WIPO Patent Application WO/2010/025968

A3

Method for enantioseparation of a chiral system with compound formation comprising a pair of enantiomers. The method comprises the steps of: placing the chiral system to be processed, which is optically enriched by a target enantiomer, in the 3-phase region (20) of the ternary phase diagram of chiral compound forming systems to achieve the establishment of the solid/liquid phase equilibria; phase-separating the liquid and solid phase formed by the placing step; shifting the eutectic composition of the remaining liquid towards a lower eutectic composition (xE) until the overall composition is located in the 2-phase region (15) of the ternary phase diagram of chiral compound forming systems; and performing crystallisation in the 2-phase region (10) of the ternary phase diagram for obtaining the target enantiomer in the solid phase. In some cases the shifting step can be skipped.

LORENZ HEIKE (DE)
KAEMMERER HENNING (DE)
POLENSKE DANIEL (DE)
SEIDEL-MORGENSTERN ANDREAS (DE)

PCT/EP2009/057562

May 14, 2010

June 18, 2009

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MAX PLANCK GESELLSCHAFT (DE)
LORENZ HEIKE (DE)
KAEMMERER HENNING (DE)
POLENSKE DANIEL (DE)
SEIDEL-MORGENSTERN ANDREAS (DE)

C07C227/34; C07B57/00; C07C229/22; C07C323/58

WO2001042173A2	2001-06-14
WO1997041084A1	1997-11-06
WO2003097582A2	2003-11-27

EP0694514A2	1996-01-31
DE102005039501A1	2007-02-22
JPS54160303A	1979-12-19
JP2000063350A	2000-02-29
US20040198778A1	2004-10-07

HANNKE BITTNER & PARTNER (Ägidienplatz 7, Regensburg, DE)

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