PROCESS FOR EXTRACTING POLYPHENOLIC ANTIOXIDANTS FROM PURINE-CONTAINING PLANTS

Title:

PROCESS FOR EXTRACTING POLYPHENOLIC ANTIOXIDANTS FROM PURINE-CONTAINING PLANTS

Document Type and Number:

WIPO Patent Application WO/2000/045769

Kind Code:

A2

Abstract:

A process for isolating polyphenolic antioxidants from purine-containing plant material, comprising the steps of: (a) extracting the plant material with a hydroxylic extracting liquid preferably at low temperature; (b) selectively adsorbing the extract obtained in step (a), preferably at low temperature; and (c) desorbing the adsorbed material with a hydroxylic desorbing liquid, preferably at relatively high temperature. The process is especially suitable for producing cocoa antioxidants of use in pharmaceutical, cosmetic and nutritional compositions.

See also references of EP 1156815A2

Attorney, Agent or Firm:

Goldstein, Jorge A. (Kessler Goldstein & Fox P.L.L.C. Suite 600 1100 New York Avenu, N.W. Washington DC, US)

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Claims:

What Is Claimed Is:

1.

A process for isolating polyphenolic antioxidants from purine containing plant material, comprising: (a) extracting the plant material with a hydroxylic extracting liquid; (b) selectively adsorbing the extract obtained in step (a) on a solid adsorbent which has a high polyphenol/purine adsorption selectivity; and (c) desorbing the adsorbed material with a hydroxylic desorbing liquid.

2.	A process according to claim 1, in which the desorbed material is concentrated and optionally dried.

3.	A process according to claim 1, in which the adsorbent comprises polyvinylpolypyrrolidone or a chemical or physical modification thereof.

4.	A process according to any one of the preceding claims, in which the adsorbent comprises chitosan or a chemical or physical modification thereof.

5.	A process according to any one of the preceding claims, in which step (a) is carried out at a temperature below 50°C, preferably between 0 and 30°C.

6.	A process according to any one of the preceding claims, in which step (b) is carried out at a temperature below 30°C.

7.	A process according to any one of the preceding claims, in which step (c) is carried out at a temperature above 30°C, preferably between 50 and 110°C.

8.	A process according to any one of the preceding claims, in which the hydroxylic extracting liquid in step (a) comprises water.

9.	A process according to any one of the preceding claims, in which the hydroxylic desorbing liquid in step (c) comprises water and a lower alcohol or water and a lower ketone.

10.	A process according to any one of the preceding claims, in which said purinecontaining plant material is cocoa, coffee or tea, especially cocoa.

11.

A watersoluble antioxidant composition obtainable using the process of any one of claims 110, which is free of chlorinated hydrocarbons and substantially fatfree, and which contains at least 15% by weight in total of catechin, epicatechin and/or chlorogenic acid, less than 5% by weight of purine components, less than 0.5% by weight of caffeine and has a TEAC value of at least 0.4.

12.	A composition according to claim 11, which contains at least 20% by weight in total of catechin and epicatechin, and/or has a TEAC value of at least 0.6.

13.	A composition according to claim 11 or 12, which contains at least 25% by weight in total of catechin and epicatechin and/or less than 0.4% by weight of caffeine and/or less than 3% by weight of theobromine, and/or has a TEAC value of at least 0.8.

14.	A nutritional, pharmaceutical or cosmetic composition containing an antioxidant composition according to any one of claims 1113.

Description:

INTERNATIONALSEARCHREPORT InternationalapplicationNo. PC17USOO/024H BoxIObservationswherecertainclaimswerefoundunsearchable(Cont inuationofitem1offirstsheet) Thisinternationalreporthasnotbeenestablishedinrespectofcerta inclaimsunderArticle17(2Xa)forthefollowingreasons: 1.2Claims Nos.: becausetheyrelatetosubjectmatternotrequiredtobesearchedbythi sAuthority,namely: 2.2Claims Nos.: becausetheyrelatetopartsoftheinternationalapplicationthatdon otcomplywiththeprescribedrequirementstosuch anextentthatnomeaningfulinternationalsearchcanbecarriedout,s pecifically: 3.ClaimsNos.:5-14 becausetheyaredependentclaimsandarenotdraftedinaccordancewit hthesecondandthirdsentencesofRule6.4(a). BoxIIObservationswhereunityofinventionislacking(Continuation ofitem2offirstsheet) ThisInternationalSearchingAuthorityfoundmultipleinventionsin thisintemationalapplication,asfollows: l.As allrequiredadditionalsearchfeesweretimelypaidbytheapplicant, thisintemationalsearchreportcoversallsearchable LJ claims. 2.g As allsearchableclaimscouldbesearchedwithouteffortjustifyingana dditionalfee,thisAuthoritydidnotinvitepayment ofanyadditionalfee. 3.Asonlysomeoftherequiredadditionalsearchfeesweretimelypaidb ytheapplicant,thisinternationalsearchreportcovers onivthoseclaimsforwhichfeeswerepaid,specificallyclaimsNos.: 4.Norequiredadditionalsearchfeesweretimelypaidbytheapplicant .Consequently.thisinternationalsearchreportis restnctedtotheinventionfirstmentionedintheclaims ; itiscoveredbvclaimsNos.: RemarkonProtestTheadditionalsearchfeeswereaccompaniedbytheap plicant'sprotest. No protest accompaniedthepavmentofadditionalsearchfees.

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