Title:
PROCESS FOR IDENTIFYING DRUGS FOR TREATING GASTROESOPHAGEAL REFLUX
Document Type and Number:
WIPO Patent Application WO/2010/075388
Kind Code:
A3
Abstract:
Methods for identifying modulators of gastroesophageal smooth muscle relaxation include isolating various types of smooth muscle fibers from the stomach or esophagus and inducing the fibers to contract. The isolated and contracted fibers are used to screen test compounds for the compound's capacity to modulate relaxation of the smooth muscle fibers. In addition, newly identified unique nicotinic acetylcholine receptors are expressed in a cell, and used to screen test compounds for the compound's capacity to modulate the biological activity of the receptors.
Inventors:
RUGGIERI MICHAEL R (US)
MILLER LARRY S (US)
BRAVERMAN ALAN STUART (US)
VEGESNA ANIL K (US)
BARBE MARY F (US)
MILLER LARRY S (US)
BRAVERMAN ALAN STUART (US)
VEGESNA ANIL K (US)
BARBE MARY F (US)
Application Number:
PCT/US2009/069203
Publication Date:
September 10, 2010
Filing Date:
December 22, 2009
Export Citation:
Assignee:
UNIV TEMPLE (US)
RUGGIERI MICHAEL R (US)
MILLER LARRY S (US)
BRAVERMAN ALAN STUART (US)
VEGESNA ANIL K (US)
BARBE MARY F (US)
RUGGIERI MICHAEL R (US)
MILLER LARRY S (US)
BRAVERMAN ALAN STUART (US)
VEGESNA ANIL K (US)
BARBE MARY F (US)
International Classes:
G01N33/50
Domestic Patent References:
| WO1995006664A1 | 1995-03-09 |
Other References:
A.K. VEGESNA ET AL.: "Cholinergic induced relaxation of the gastric clasp fibers may mediate TLESR in humans", GASTROENTEROLOGY, vol. 134, no. 4, Suppl. 1, April 2008 (2008-04-01), DIGESTIVE DISEASE WEEK MEETING/109TH ANNUAL MEETING OF THE AMERICAN-GASTROENTEROLOGICAL-ASSOCIATION; SAN DIEGO, CA, USA; MAY 17 22, 2008, pages A715, XP002578212, ISSN: 0016-5085
RUGGIERI M R ET AL: "T1220 Pharmacologic Specificity of Nicotinic Receptors Mediating Relaxation of Muscarinic Receptor Pre-Contracted Human and Pig Gastric Clasp Fibers", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA USA, vol. 136, no. 5, 1 May 2009 (2009-05-01), pages A - 525, XP026112962, ISSN: 0016-5085, [retrieved on 20090501]
RUGGIERI M R ET AL: "T1220 Pharmacologic Specificity of Nicotinic Receptors Mediating Relaxation of Muscarinic Receptor Pre-Contracted Human and Pig Gastric Clasp Fibers", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA USA, vol. 136, no. 5, 1 May 2009 (2009-05-01), pages A - 525, XP026112962, ISSN: 0016-5085, [retrieved on 20090501]
Attorney, Agent or Firm:
WEED, Stephen, J. et al. (P.O. Box 980Valley Forge, PA, US)
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