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Patent Searching and Data


Title:
PROCESS FOR INDUSTRIALLY PRODUCING OPTICALLY ACTIVE 1,4-BENZODIOXANE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2004/011451
Kind Code:
A1
Abstract:
A process for easily and safely producing from inexpensive materials an optically active 1,4-benzodioxane derivative useful as an intermediate for medicines, etc. The process comprises sulfonylating an optically active triol compound (5) obtained by the reaction of catechol (2) with an optically active 3-halogeno-1,2-propanediol (3) to obtain an optically active trisulfonate (6) and cyclizing the trisulfonate (6) with a base to produce an optically active 1,4-benzodioxane (1).

Inventors:
Tanaka, Tatsuyoshi c/o KANEKA CORPORATION (1-8 Miyamaecho, Takasagoch, Takasago-shi Hyogo, 676-8688, JP)
Mitsuda, Masaru c/o KANEKA CORPORATION (1-8 Miyamaecho, Takasagoch, Takasago-shi Hyogo, 676-8688, JP)
Application Number:
PCT/JP2003/009125
Publication Date:
February 05, 2004
Filing Date:
July 17, 2003
Export Citation:
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Assignee:
KANEKA CORPORATION (2-4 Nakanoshima 3-Chome, Kita-ku Osaka-shi, Osaka, 530-8288, JP)
Tanaka, Tatsuyoshi c/o KANEKA CORPORATION (1-8 Miyamaecho, Takasagoch, Takasago-shi Hyogo, 676-8688, JP)
Mitsuda, Masaru c/o KANEKA CORPORATION (1-8 Miyamaecho, Takasagoch, Takasago-shi Hyogo, 676-8688, JP)
International Classes:
C07D319/20; (IPC1-7): C07D319/20; C07C41/03; C07C41/16; C07C43/23; C07C303/28; C07C309/66; C07C303/73
Foreign References:
JP2001081086A2001-03-27
US5780650A1998-07-14
DE4040186A11991-06-27
JP2001316385A2001-11-13
EP0928791A11999-07-14
Other References:
DELGADO ANTONIO ET AL.: 'Short and enantioselective syntheses of (R)- and (S)-2-hydroxymethyl-1,4-benzodioxan' TETRAHEDRON LETTERS vol. 29, no. 30, 1988, pages 3671 - 3674, XP002005147
CHEN JIAN ET AL.: 'A practical synthetic route to enantiopure 2-aryloxy-1,2-propanediols from chiral glycidol' TETRAHEDRON LETTERS vol. 36, no. 14, 1995, pages 2379 - 2380, XP004028288
NELSON WENDEL L. ET AL.: 'Absolute configuration of glycerol derivatives. 4. Synthesis and pharmacological activity of chiral 2-alkylaminomethyl benzodioxans, competitive alpha-adrenergic antagonists' JOURNAL OF MEDICINAL CHEMISTRY vol. 20, no. 7, 1977, pages 880 - 885, XP002005148
Attorney, Agent or Firm:
KANEKA CORPORATION (2-4 Nakanoshima 3-Chome, Kita-ku Osaka-shi, Osaka, 530-8288, JP)
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